Toxicology of blister agents: is melatonin a potential therapeutic option?
| Autor: | Francisco López-Muñoz, Alejandro Romero, Eva Ramos, René Pita, Emilio Gil-Martín, Dolores R. Serrano, Cristóbal de los Ríos, Antonio Juberias, Juan J. Torrado, Javier Egea |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
safety Chemical Warfare Agents DNA damage sulfur and nitrogen mustard lcsh:Medicine Context (language use) melatonin Review Pharmacology Salud Pública 3210 Medicina Preventiva medicine.disease_cause First world war Melatonin 03 medical and health sciences chemistry.chemical_compound Tecnología farmaceútica 0302 clinical medicine 2302 Bioquímica Toxicología medicine oxidative stress business.industry lcsh:R galenic formulation Farmacia Guerra Nitrogen mustard 030104 developmental biology Mechanism of action chemistry inflammation 3209 Farmacología medicine.symptom business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Investigo. Repositorio Institucional de la Universidade de Vigo Universidade de Vigo (UVigo) Diseases, Vol 9, Iss 27, p 27 (2021) Diseases |
| Popis: | Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins, but also produce free radicals that can develop direct toxic effects in target organs such as the eyes, skin, and respiratory system. The lack of effective treatments against vesicant CWAs-induced injury makes us consider, in this complex scenario, the use and development of melatonin-based therapeutic strategies. This multifunctional indoleamine could facilitate neutralization of the oxidative stress, modulate the inflammatory response, and prevent the DNA damage, as well as the long-term health consequences mediated by vesicant CWAs-induced epigenetic mechanisms. In this context, it would be essential to develop new galenic formulations for the use of orally and/or topically applied melatonin for the prophylaxis against vesicant CWAs, as well as the development of post-exposure treatments in the near future. Universidad Camilo José Cela | Ref. QUIMELTER Ministerio de Defensa | Ref. MELVES |
| Databáze: | OpenAIRE |
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