Sirolimus-eluting stent versus balloon angioplasty for sirolimus-eluting stent restenosis: Insights from the j-Cypher Registry
| Autor: | Yu Kataoka, Hiroki Shiomi, Kenji Horiuchi, Nobuyuki Morioka, Nobuhito Yagi, Yoichiro Kasahara, Hiroshi Nonogi, Atsushi Kawamura, Koichi Nakao, Koichi Kishi, Futoshi Yamanaka, Takuya Taniguchi, Tsukasa Inada, Nobuaki Kokubu, Akira Ito, Kazuaki Mitsudo, Takeshi Kimura, Manabu Setoguchi, Hiroshi Hoshizaki, Mitsuru Abe, Hiroki Sakamoto, Yoritaka Otsuka, Shunichi Miyazaki, Ren Kawaguchi, Masao Imai, Takeshi Morimoto, Kazuhiro Nakao |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty medicine.medical_treatment Revascularization Balloon Coronary Angiography Coronary Restenosis Restenosis Japan Renal Dialysis Risk Factors Physiology (medical) Angioplasty medicine Myocardial Revascularization Secondary Prevention Humans Cumulative incidence Prospective Studies Registries Acute Coronary Syndrome Coronary Artery Bypass Aged Aged 80 and over Sirolimus business.industry Graft Occlusion Vascular Stent Drug-Eluting Stents Middle Aged medicine.disease Surgery Female Cardiology and Cardiovascular Medicine business Angioplasty Balloon medicine.drug Follow-Up Studies |
| Zdroj: | Circulation. 122(1) |
| ISSN: | 1524-4539 |
| Popis: | Background— Optimal treatment strategies for restenosis of sirolimus-eluting stents (SES) have not been adequately addressed yet. Methods and Results— During the 3-year follow-up of 12 824 patients enrolled in the j-Cypher registry, 1456 lesions in 1298 patients underwent target-lesion revascularization (TLR). Excluding 362 lesions undergoing TLR for stent thrombosis or TLR using treatment modalities other than SES or balloon angioplasty (BA), 1094 lesions with SES-associated restenosis in 990 patients treated with either SES (537 lesions) or BA (557 lesions) constituted the study population for the analysis of recurrent TLR and stent thrombosis after the first TLR. Excluding 24 patients with both SES- and BA-treated lesions, 966 patients constituted the analysis set for the mortality outcome. Cumulative incidence of recurrent TLR in the SES-treated restenosis lesions was significantly lower than that in the BA-treated restenosis lesions (23.8% versus 37.7% at 2 years after the first TLR; P P P =0.4) and 0.6% versus 0.6%, respectively. Conclusions— Repeated implantation of SES for SES-associated restenosis is more effective in preventing recurrent TLR than treatment with BA, without evidence of safety concerns. |
| Databáze: | OpenAIRE |
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