The Sensitivity and Specificity of Using a Computer Aided Diagnosis Program for Automatically Scoring Chest X-Rays of Presumptive TB Patients Compared with Xpert MTB/RIF in Lusaka Zambia
| Autor: | Rosanna Spooner, Bram van Ginneken, Helen Ayles, Nkatya Kasese, Monde Muyoyeta, Pragnya Maduskar, Deborah Milimo, Nathan Kapata, Maureen Moyo, Laurens Hogeweg |
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| Rok vydání: | 2014 |
| Předmět: |
Bacterial Diseases
Health Screening Radiography CAD Computer Applications Diagnostic Radiology Medicine and Health Sciences Public and Occupational Health Multidisciplinary Radiology and Imaging Physics Electromagnetic Radiation Bacterial Pathogens Infectious Diseases Medical Microbiology Predictive value of tests Area Under Curve Physical Sciences Computer-Aided Design Medicine Radiology medicine.symptom Research Article Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] medicine.medical_specialty Computer and Information Sciences Tuberculosis Science Zambia Hiv testing Microbiology Sensitivity and Specificity Diagnostic Medicine Predictive Value of Tests Image Interpretation Computer-Assisted medicine Humans Microbial Pathogens Tuberculosis Pulmonary X-Radiation Receiver operating characteristic business.industry Sputum Biology and Life Sciences Mycobacteria Radiobiology Mycobacterium tuberculosis medicine.disease Tropical Diseases Mass Chest X-Ray Surgery Microscopy Fluorescence ROC Curve Computer-aided diagnosis business |
| Zdroj: | PLoS One, 9 PLoS ONE, Vol 9, Iss 4, p e93757 (2014) PLoS One, 9, 4 PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Contains fulltext : 136965.pdf (Publisher’s version ) (Open Access) To determine the sensitivity and specificity of a Computer Aided Diagnosis (CAD) program for scoring chest x-rays (CXRs) of presumptive tuberculosis (TB) patients compared to Xpert MTB/RIF (Xpert).Consecutive presumptive TB patients with a cough of any duration were offered digital CXR, and opt out HIV testing. CXRs were electronically scored as normal (CAD score ≤60) or abnormal (CAD score>60) using a CAD program. All patients regardless of CAD score were requested to submit a spot sputum sample for testing with Xpert and a spot and morning sample for testing with LED Fluorescence Microscopy-(FM).Of 350 patients with evaluable data, 291 (83.1\%) had an abnormal CXR score by CAD. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CXR compared to Xpert were 100\% (95\%CI 96.2-100), 23.2\% (95\%CI 18.2-28.9), 33.0\% (95\%CI 27.6-38.7) and 100\% (95\% 93.9-100), respectively. The area under the receiver operator curve (AUC) for CAD was 0.71 (95\%CI 0.66-0.77). CXR abnormality correlated with smear grade (r = 0.30, p |
| Databáze: | OpenAIRE |
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