Prevalence and Course of IgA and IgG Antibodies against SARS-CoV-2 in Healthcare Workers during the First Wave of the COVID-19 Outbreak in Germany: Interim Results from an Ongoing Observational Cohort Study
| Autor: | Mark Reinwald, Henrike Andresen, Andreas G. Schreyer, Werner Dammermann, Peter Markus Deckert, Karsten Henrich Weylandt, Oliver Ritter, Stefan Lüth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Leadership and Management Health Informatics Asymptomatic Article 03 medical and health sciences 0302 clinical medicine Health Information Management Internal medicine Germany Health care Pandemic medicine Seroprevalence Medical history 030212 general & internal medicine first wave 030304 developmental biology IgG response 0303 health sciences biology seroprevalence business.industry SARS-CoV-2 healthcare workers Health Policy Outbreak virus diseases COVID-19 anti-SARS-CoV-2 IgA biology.protein Medicine symptoms medicine.symptom Antibody business Cohort study |
| Zdroj: | Healthcare Volume 9 Issue 5 Healthcare, Vol 9, Iss 498, p 498 (2021) |
| ISSN: | 2227-9032 |
| DOI: | 10.3390/healthcare9050498 |
| Popis: | (1) Background: Healthcare workers (HCWs) are prone to intensified exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the ongoing pandemic. We prospectively analyzed the prevalence of antibodies against SARS-CoV-2 in HCWs at baseline and follow up with regard to clinical signs and symptoms in two university hospitals in Brandenburg, Germany. (2) Methods: Screening for anti-SARS-CoV-2 IgA and IgG antibodies was offered to HCWs at baseline and follow up two months thereafter in two hospitals of Brandenburg Medical School during the first wave of the COVID-19 pandemic in Germany in an ongoing observational cohort study. Medical history and signs and symptoms were recorded by questionnaires and analyzed. (3) Results: Baseline seroprevalence of anti-SARS-CoV-2 IgA was 11.7% and increased to 15% at follow up, whereas IgG seropositivity was 2.1% at baseline and 2.2% at follow up. The rate of asymptomatic seropositive cases was 39.5%. Symptoms were not associated with general seropositivity for anti-SARS-CoV-2 however, class switch from IgA to IgG was associated with increased symptom burden. (4) Conclusion: The seroprevalence of antibodies against SARS-CoV-2 was low in HCWs but higher compared to population data and increased over time. Screening for antibodies detected a significant proportion of seropositive participants cases without symptoms. |
| Databáze: | OpenAIRE |
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