Volatile fluorinated nanoemulsions: A chemical route to controlled delivery of inhalation Anesthesia
| Autor: | Antony Robert Wilkes, Ibrahim E. Salama, Alun M. Davies, Judith Elizabeth Hall, Alison Paul, Jeffrey N. Clark, Claire L. Jenkins |
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| Rok vydání: | 2015 |
| Předmět: |
Methyl Ethers
Inhalation Chemistry Evaporation food and beverages Fluorine Inhalation anesthesia Sevoflurane Surfaces Coatings and Films Electronic Optical and Magnetic Materials Biomaterials Creaming Colloid and Surface Chemistry Chemical engineering Controlled delivery Anesthetics Inhalation Emulsion Anesthetic medicine Organic chemistry Emulsions Volatilization medicine.drug |
| Zdroj: | Journal of Colloid and Interface Science. 440:78-83 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2014.10.021 |
| Popis: | Novel dispersions of the volatile inhalation anesthetic sevoflurane have been formulated that can provide controlled, sustainable release of anesthetic over clinically useful timescales. The emulsions can be simply formed with manual shaking, reproducibly yielding droplets of the order of 250 nm diameter, i.e. within the nanoemulsion range. Using a custom flow-rig, release of anesthetic gas from the emulsion has been evaluated, and clinically useful levels achieved through appropriate stirring of the formulation. Stirring can also be used to temporarily increase or decrease the amount of anesthetic released. Once consideration of the unusual nature of the fluorinated systems (phase separation by sedimentation rather than creaming), and the highly perturbed environment of their evaluation (under stirring and flow of gas), the observed behavior regarding sevoflurane evaporation can be reasonably well explained by existing theoretical models. Links between anesthetic release and emulsion structure have been defined, providing the basis for future development. |
| Databáze: | OpenAIRE |
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