Localization and postoperative follow-up of a bronchial carcinoid tumor causing Cushing’s syndrome by 111In-DTPA labelled octreotide scintigraphy
| Autor: | L. Flores, F. Fernandez-Fernandez, Irene Halperin, J. M. Manzanares, F. Lomeña, Vilardell E |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Pathology Endocrinology Diabetes and Metabolism Carcinoid Tumor Octreotide Scintigraphy Dexamethasone Cushing syndrome Endocrinology Adrenocorticotropic Hormone Octreotide scintigraphy medicine Humans Radionuclide Imaging Cushing Syndrome Glucocorticoids Bronchus S syndrome medicine.diagnostic_test business.industry Bronchial Neoplasms Indium Radioisotopes Respiratory disease BRONCHIAL CARCINOID TUMOR Pentetic Acid medicine.disease Occult Kinetics medicine.anatomical_structure Radiology business |
| Zdroj: | Journal of Endocrinological Investigation. 20:327-330 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03350311 |
| Popis: | Bronchial carcinoid tumor is the most frequent occult source of ectopic ACTH-dependent Cushing’s syndrome, but its initial localization may be very difficult, as well as its postoperative follow-up. We here present the case of a 21 -year-old man with Cushing’s syndrome and biochemical findings suggesting an ectopic source of ACTH (lack of inhibition of Cortisol after overnight 8-mg dexametha-sone supression test, and lack of response to h-CRH challenge). Chest CT-scan showed a node adjacent to the left lung hilium whose nature was confirmed by uptake of 111Indium-DTPA labelled octreotide scintigraphy. Surgical resection of the tumor consisted in an upper lobectomy of the left lung. Microscopic examination identified a typical carcinoid tumor. After surgery pituitary-adrenal function normalized and a second scintigraphy offered additional data on the absence of tumor remnants. |
| Databáze: | OpenAIRE |
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