Identification of 33 candidate oncogenes by screening for base-specific mutations
| Autor: | Laura Renkonen-Sinisalo, Johanna Kondelin, Ulrika A. Hänninen, Jan Böhm, P. von Nandelstadh, Tatiana Cajuso, Riku Katainen, Sari Tuupanen, Minna Taipale, Kaisa Lehti, Claus L. Andersen, Heikki Järvinen, Mecklin Jp, Esa Pitkänen, Pia Vahteristo, Heikki Ristolainen, Tomas Tanskanen, Lauri A. Aaltonen, Alexandra E. Gylfe, Jussi Taipale |
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| Rok vydání: | 2014 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Cancer Research Somatic cell colorectal cancer Biology medicine.disease_cause Germline mutation oncogene Neoplasms medicine Humans Database search engine Gene Exome sequencing Genetics Microsatellite instability Genetics and Genomics Oncogenes medicine.disease 3. Good health Oncology Mutation Microsatellite Instability mutation hotspot Skin cancer Carcinogenesis exome sequencing |
| Zdroj: | Tuupanen, S, Hänninen, U A, Kondelin, J, von Nandelstadh, P, Cajuso, T, Gylfe, A E, Katainen, R, Tanskanen, T, Ristolainen, H, Böhm, J, Mecklin, J-P, Järvinen, H, Renkonen-Sinisalo, L, Andersen, C L, Taipale, M, Taipale, J, Vahteristo, P, Lehti, K, Pitkänen, E & Aaltonen, L A 2014, ' Identification of 33 candidate oncogenes by screening for base-specific mutations ', B J C, pp. 1657-1662 . https://doi.org/10.1038/bjc.2014.429 British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2014.429 |
| Popis: | Background:Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations.Methods:We utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorectal cancers (CRCs) and searched for base-specific somatic mutation hotspots.Results:We identified novel mutation hotspots in 33 genes. Fourteen genes displayed mutations in the validation set of 254 MSI CRCs: ANTXR1, MORC2, CEP135, CRYBB1, GALNT9, KRT82, PI15, SLC36A1, CNTF, GLDC, MBTPS1, OR9Q2, R3HDM1 and TTPAL. A database search found examples of the hotspot mutations in multiple cancer types.Conclusions:This work reveals a variety of new recurrent candidate oncogene mutations to be further scrutinised as potential therapeutic targets.British Journal of Cancer advance online publication, 12 August 2014; doi:10.1038/bjc.2014.429 www.bjcancer.com. |
| Databáze: | OpenAIRE |
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