Association between PAX8AS1 (rs4848320 C > T, rs1110839 G > T, and rs6726151 T > G) and MEG3 (rs7158663) gene polymorphisms and non-Hodgkin lymphoma risk

Autor:	Samaneh Mirzazadeh, Hosna Sarani, Alireza Nakhaee, Seyed-Mehdi Hashemi, Mohsen Taheri, Mohammad Hashemi, Gholamreza Bahari
Rok vydání:	2022
Předmět:	Case-Control Studies Lymphoma Non-Hodgkin Genetics Humans Molecular Medicine Genetic Predisposition to Disease RNA Antisense RNA Long Noncoding General Medicine Polymorphism Single Nucleotide Biochemistry
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids. 41:1174-1186
ISSN:	1532-2335 1525-7770
DOI:	10.1080/15257770.2022.2104870
Popis:	Long non-coding RNA (lncRNA) PAX8 antisense RNA 1 (PAX8AS1) and Maternal-expressed gene 3 (MEG3) contribute to the pathogenesis of various malignancies including non-Hodgkin lymphoma (NHL). In this study, we aimed to examine the possible association of polymorphisms of PAX8 and MEG3 and the risk NHL. A total of 175 patients and 175 healthy subjects were genotyped by PCR-RFLP and Tetra-Arms PCR assays. Results demonstrated rs4848320 C T and rs6726151 T G of PAX8AS1 and rs7158663 of MEG3 play a potential role in the susceptibility of NHL and PAX8AS1 rs1110839 T G variant was associated with decreased risk of NHL. Haplotype analysis of rs1110839, rs4848320, and rs6726151 demonstrated GCG haplotype is associated with increased risk of lymphoma and TTG, TTT, and GTT haplotypes are related to decreased lymphoma susceptibility.
Databáze:	OpenAIRE
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