Importance of membrane-bound antigens of Toxoplasma gondii and their fixation for serodiagnosis of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome
| Autor: | Y Suzuki, J S Remington |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Microbiology (medical)
Antigens Protozoan Opportunistic Infections Serology Antigen Agglutination Tests Direct agglutination test medicine Animals Humans Serologic Tests Fixation (histology) Acquired Immunodeficiency Syndrome biology Toxoplasma gondii medicine.disease biology.organism_classification Virology Toxoplasmosis Titer Evaluation Studies as Topic Immunology Encephalitis Toxoplasma Research Article |
| Zdroj: | Journal of Clinical Microbiology. 28:2354-2356 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | Titers in a direct agglutination test using Formalin-fixed toxoplasma tachyzoites were significantly higher in patients with acquired immunodeficiency syndrome with toxoplasmic encephalitis (TE) than in those without TE. In contrast, when fresh (not fixed) tachyzoites were used, the titers did not differ from those in patients without TE. The direct agglutination test using Formalin-fixed tachyzoites better distinguished between patients with TE and those without TE than an agglutination test using latex particles coated with Formalin-fixed sonicated-tachyzoite antigens. Thus, both selective use of membrane-bound antigens and their fixation are important for serodiagnosis of TE in patients with acquired immunodeficiency syndrome. |
| Databáze: | OpenAIRE |
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