Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
| Autor: | Jun Zhang, Zhian Hu, Guan-Zhong Wang, Jing Chen, Hui Feng, Qi-Cheng Qiao, Si-Yi Wen, Jiao Cai, Hao-Yi Li, Yu-Jie Pang, Fen-Lan Luo, Nian Yang, Sheng-Yun Wang, Kai-Xuan Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hypocretin Science General Physics and Astronomy Optogenetics General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Muscle tone 0302 clinical medicine mental disorders medicine lcsh:Science Multidisciplinary Chemistry digestive oral and skin physiology Gap junction Eye movement General Chemistry Sleep in non-human animals Orexin 030104 developmental biology medicine.anatomical_structure nervous system lcsh:Q Wakefulness REM sleep Neuroscience Nucleus 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here, we find that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus (SLD) and exhibit REM sleep-related activation. In SLD, orexin directly excites orexin receptor-positive neurons (occupying ~3/4 of total-population) and increases gap junction conductance among neurons. Their interaction spreads the orexin-elicited partial-excitation to activate SLD network globally. Besides, the activated SLD network exhibits increased probability of synchronized firings. This synchronized excitation promotes the correspondence between SLD and its downstream target to enhance SLD output. Using optogenetics and fiber-photometry, we consequently find that orexin-enhanced SLD output prolongs REM sleep episodes through consolidating brain state activation/muscle tone inhibition. After chemogenetic silencing of SLD orexin signaling, a ~17% reduction of REM sleep amounts and disruptions of REM sleep muscle atonia are observed. These findings reveal a stabilization role of orexin in REM sleep. Orexin signaling is provided by diffusely distributed fibers and involved in different brain circuits that orchestrate sleep and wakefulness states. Here, the authors show that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus and exhibit rapid eye movement (REM) sleep-related actions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|