Association of erosive hand osteoarthritis with a single nucleotide polymorphism on the gene encoding interleukin-1 beta
| Autor: | G Moxley, M.R.C de Carvalho, T.P.S Rao, R.A Adler, Gregory A. Buck, D. Disler, A.G Stern |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genetic Markers
Male Linkage disequilibrium Genotype Population Biomedical Engineering Single-nucleotide polymorphism Biology Population stratification Polymorphism Single Nucleotide Linkage Disequilibrium Genetic Rheumatology Osteoarthritis Humans SNP Orthopedics and Sports Medicine education Alleles Aged Genetics education.field_of_study Haplotype Chromosome Mapping Receptors Interleukin-1 Middle Aged Tag SNP Hand Radiography Tandem Repeat Sequences Female Interleukin-1 |
| Zdroj: | Osteoarthritis and Cartilage. 11:394-402 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/s1063-4584(03)00054-2 |
| Popis: | Objective: Certain forms of primary osteoarthritis (OA), particularly those affecting hand joints, have a genetic component. Recent studies have shown suggestive evidence that hand and knee OA are linked with the interleukin-1 (IL-1) region on human chromosome 2q. This study was undertaken to assess the association of primary OA of the hand (hand OA) with IL-1 region markers.Methods: Sixty-eight US Caucasoid cases and 51 US Caucasoid controls aged 60 years or older were recruited from the Mid-Atlantic region of the United States. Hand OA was classified by American College of Rheumatology (ACR) Clinical Criteria, and cases were subjected to radiographic examination for subgrouping. Genotyping was done for seven previously described single nucleotide polymorphisms (SNPs) of genes for IL-1α (encoded by IL1A), IL-1β (IL1B), and the IL-1 receptor antagonist (IL1RN), as well as an IL1RN variable number of tandem repeat (VNTR) marker. Six microsatellite markers on other chromosomes (null loci) were also typed.Results: The IL1B 5810 G>A SNP genotypes marker were not in Hardy–Weinberg equilibrium (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect