Helicobacter pylori co-infection with Epstein-Barr virus and the risk of developing gastric adenocarcinoma at an early age: Observational study infectious agents and cancer
| Autor: | Othmane Elyamine, Moulay Mustapha Ennaji, Farid F. Chehab, Fatima Ezzahra Rihane, Driss Erguibi, Berjas Abumsimir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Experimental Research Population medicine.disease_cause Gastroenterology Virus Epstein-barr virus Age Internal medicine medicine Clinical significance Stage (cooking) education education.field_of_study biology Helicobacter pylori business.industry Cancer General Medicine medicine.disease biology.organism_classification Epstein–Barr virus Co-infection Adenocarcinoma Surgery business Gastric cancer |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Background Gastric cancer (GC) is one of the leading causes of morbidity and mortality worldwide. The onset and progression of gastric cancer are attributed to numerous triggers, these triggers may be infection of the gastric epithelium by Helicobacter pylori (H. pylori), or by Epstein-Barr virus (EBV). Both agents can establish a lifelong persistent infection in the host, leading to chronic inflammation, which also contributes to cancer development. Objective: The objective of this study is to present the status of co-infection with H. pylori and EBV and the risk of developing adenocarcinoma at an early age in the population of Grand Casablanca. Methods In this study, 100 gastric tissue samples from patients with gastric cancer were examined for detection of H. pylori and EBV in tumor tissue using PCR techniques, and the clinical relevance was statistically analyzed. Results Results revealed an individual Epstein-Barr virus (EBV) infection observed in (40 %) of gastric carcinoma cases. Furthermore, the frequency of EBV infection was significantly different with intestinal and diffuse gastric cancer types [15 % vs. 85 % Highlights Determination of the frequency of H. pylori and EBV infections Correlation between co-infection and age of gastric cancer patients Evaluation of the clinicopathological features associated with the presence of infectious agents. |
| Databáze: | OpenAIRE |
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