A comparative research on obesity hypertension by the comparisons and associations between waist circumference, body mass index with systolic and diastolic blood pressure, and the clinical laboratory data between four special Chinese adult groups
| Autor: | Qi Pan, Jia-Jia Li, Jian-Hang Leng, Xingyu Zhang, Hai-Ming Yang, Bing Liu, Chengjian Cao, Zeng-Fang Li, Hu Zhang, Fen-Fang Yang, Qingmin Liu, Yanjun Ren, Wei Liu, Ou Wu, Cheng-Da Yuan |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male Physiology Blood Pressure 030204 cardiovascular system & hematology Body Mass Index chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Diastole Risk Factors Alanine Transaminase General Medicine gamma-Glutamyltransferase Middle Aged Fructosamine Phenotype Hypertension Female Waist Circumference Adult medicine.medical_specialty China Systole 030209 endocrinology & metabolism 03 medical and health sciences Young Adult Internal medicine Internal Medicine medicine Humans Obesity Serum Albumin Triglycerides Aged Creatinine Triglyceride business.industry Cholesterol Cholesterol HDL Albumin Bilirubin Cholesterol LDL Alkaline Phosphatase Uric Acid Endocrinology Cross-Sectional Studies chemistry Uric acid business Body mass index |
| Zdroj: | Clinical and experimental hypertension (New York, N.Y. : 1993). 40(1) |
| ISSN: | 1525-6006 |
| Popis: | Background The obesity-hypertension pathogenesis is complex. From the phenotype to molecular mechanism, there is a long way to clarify the mechanism. To explore the association between obesity and hypertension, we correlate the phenotypes such as the waist circumference (WC), body mass index (BMI), systolic blood pressure (SB), and diastolic blood pressure (DB) with the clinical laboratory data between four specific Chinese adult physical examination groups (newly diagnosed untreated just-obesity group, newly diagnosed untreated obesity-hypertension group, newly diagnosed untreated just-hypertension group, and normal healthy group), and the results may show something. Objective To explore the mechanisms from obesity to hypertension by analyzing the correlations and differences between WC, BMI, SB, DB, and other clinical laboratory data indices in four specific Chinese adult physical examination groups. Methods This cross-sectional study was conducted from September 2012 to July 2014, and 153 adult subjects, 34 women and 119 men, from 21 to 69 years, were taken from four characteristic Chinese adult physical examination groups (newly diagnosed untreated just-obesity group, newly diagnosed untreated obesity-hypertension group, newly diagnosed untreated just-hypertension group, and normal healthy group). The study was approved by the ethics committee of Hangzhou Center for Disease Control and Prevention. WC, BMI, SB, DB, and other clinical laboratory data were collected and analyzed by SPSS. Results Serum levels of albumin (ALB)，alanine aminotransferase (ALT), low density lipoprotein cholesterol (LDLC), triglyceride (TG), high density lipoprotein cholesterol (HDLC), alkaline phosphatase (ALP), uric acid (Ua), and TC/HDLC (odds ratio) were statistically significantly different between the four groups. WC statistically significantly positively correlated with BMI, ALT, Ua, and serum levels of glucose (GLU), and TC/HDLC, and negatively with ALB, HDLC, and serum levels of conjugated bilirubin (CB). BMI was statistically significantly positively related to ALT, Ua, LDLC, WC, and TC/HDLC, and negatively to ALB, HDLC, and CB. DB statistically significantly positively correlated with ALP, BMI, and WC. SB was statistically significantly positively related to LDLC, GLU, serum levels of fructosamine (FA), serum levels of the total protein (TC), BMI, and WC. Conclusion The negative body effects of obesity are comprehensive. Obesity may lead to hypertension through multiple ways by different percents. GGT, serum levels of gamma glutamyltransferase; ALB, serum levels of albumin; ALT, serum levels of alanine aminotransferase; LDLC, serum levels of low density lipoprotein cholesterol; TG, serum levels of triglyceride; HDLC, serum levels of high density lipoprotein cholesterol; FA, serum levels of fructosamine; S.C.R, serum levels of creatinine; IB, serum levels of indirect bilirubin; ALP, serum levels of alkaline phosphatase; CB, serum levels of conjugated bilirubin; UREA, Urea; Ua, serum levels of uric acid; GLU, serum levels of glucose; TC, serum levels of the total cholesterol; TB, serum levels of the total bilirubin; TP, serum levels of the total protein; TC/HDLC, TC/HDLC ratio. |
| Databáze: | OpenAIRE |
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