Immune stimulation following dermal exposure to unsintered indium tin oxide
| Autor: | Ewa Lukomska, Carrie M. Long, Kristie Brock, Nikki B. Marshall, Stacey E. Anderson, B. Jean Meade, Katie Anderson |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Pulmonary toxicity T-Lymphocytes Immunology Pulmonary Alveolar Proteinosis Toxicology Indium Article Mice Occupational Exposure medicine Animals Humans Industry Lung Cells Cultured Cell Proliferation Immunity Cellular Mice Inbred BALB C Local lymph node assay Chemistry Tin Compounds Dermis respiratory system Tin oxide medicine.disease Fibrosis Indium tin oxide medicine.anatomical_structure Pulmonary Emphysema Mediastinal lymph node Models Animal Female Immunization Lymph Pulmonary alveolar proteinosis |
| Zdroj: | Journal of Immunotoxicology. 11:268-272 |
| ISSN: | 1547-6901 1547-691X |
| DOI: | 10.3109/1547691x.2013.843620 |
| Popis: | In recent years, several types of pulmonary pathology, including alveolar proteinosis, fibrosis, and emphysema, have been reported in workers in the indium industry. To date, there remains no clear understanding of the underlying mechanism(s). Pulmonary toxicity studies in rats and mice have demonstrated the development of mediastinal lymph node hyperplasia and granulomas of mediastinal lymph nodes and bronchus-associated lymphoid tissues following exposure to indium tin oxide. Given the association between exposure to other metals and the development of immune-mediated diseases, these studies were undertaken to begin to investigate the immuno-modulatory potential of unsintered indium tin oxide (uITO) in a mouse model. Using modifications of the local lymph node assay, BALB/c mice (five animals/group) were exposed topically via intact or breached skin or injected intradermally at the base of the ear pinnae with either vehicle or increasing concentrations 2.5–10% uITO (90:10 indium oxide/tin oxide, particle size |
| Databáze: | OpenAIRE |
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