Chimeras for the twenty-first century
| Autor: | Luis López Navas, Garikoitz Azkona, Rosario Sánchez Pernaute, Cynthia Morata Tarifa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Engineering Organogenesis Regenerative Medicine 01 natural sciences Applied Microbiology and Biotechnology Regenerative medicine 03 medical and health sciences Chimera (genetics) Mice Basic research 010608 biotechnology Genetic model Animals Humans Bioethical Issues Embryonic Stem Cells 030304 developmental biology Cognitive science 0303 health sciences Transplantation Chimera Ethical issues Models Genetic business.industry Chimera Twenty-First Century General Medicine Transplantation business Stem cell biology Biotechnology |
| Zdroj: | Critical reviews in biotechnology. 40(3) |
| ISSN: | 1549-7801 |
| Popis: | Recent advances in stem cell biology and molecular engineering have improved and simplified the methodology employed to create experimental chimeras, highlighting their value in basic research and broadening the spectrum of potential applications. Experimental chimeras have been used for decades during the generation of murine genetic models, this being especially relevant in developmental and regeneration studies. Indeed, their value for the research and modeling of human diseases was recognized by the 2007 Nobel Prize to Mario Capecchi, Martin Evans, and Oliver Smithies. More recently, their potential application in regenerative medicine has generated a lot of interest, particularly the enticing possibility to generate human organs for transplantation in livestock animals. In this review, we provide an update on interspecific chimeric organogenesis, its possibilities, current limitations, alternatives, and ethical issues. |
| Databáze: | OpenAIRE |
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