Risk factors and impact of early anastomotic biliary complications after liver transplantation: UK registry analysis
| Autor: | S J Tingle, D M Manas, G Sen, C H Wilson, Mark Hudson, S A White, S S Ali, E R Thompson, R Figueiredo |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent AcademicSubjects/MED00910 Biliary Tract Diseases medicine.medical_treatment 030230 surgery Liver transplantation Anastomosis Logistic regression Risk Assessment Young Adult 03 medical and health sciences Liver disease Postoperative Complications 0302 clinical medicine Risk Factors medicine Humans Registries Aged Retrospective Studies business.industry Proportional hazards model Incidence Incidence (epidemiology) Anastomosis Surgical Graft Survival Hazard ratio General Medicine Middle Aged medicine.disease Survival Analysis United Kingdom Liver Transplantation Surgery Transplantation Logistic Models Female Original Article 030211 gastroenterology & hepatology Bile Ducts AcademicSubjects/MED00010 business |
| Zdroj: | BJS Open |
| ISSN: | 2474-9842 |
| DOI: | 10.1093/bjsopen/zrab019 |
| Popis: | Background Biliary leaks and anastomotic strictures are common early anastomotic biliary complications (EABCs) following liver transplantation. However, there are no large multicentre studies investigating their clinical impact or risk factors. This study aimed to define the incidence, risk factors and impact of EABC. Methods The NHS registry on adult liver transplantation between 2006 and 2017 was reviewed retrospectively. Adjusted regression models were used to assess predictors of EABC, and their impact on outcomes. Results Analyses included 8304 liver transplant recipients. Patients with EABC (9·6 per cent) had prolonged hospitalization (23 versus 15 days; P Early anastomotic biliary complications are common following liver transplantation. In this national registry analysis we show that these complications have a significant, independent, impact on graft loss and mortality following transplantation. We also identify a number of key risk factors for development of early anastomotic biliary complications. |
| Databáze: | OpenAIRE |
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