Evaluation of disease activity in IBD at the time of diagnosis by the use of clinical, biochemical, and fecal markers
| Autor: | Øyvind Holme, Jon Sponheim, Andreas Rydning, Stephan Brackmann, Lars Gustav Lyckander, Morten H. Vatn, Petr Ricanek, Gøri Perminow, Ole Høie |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Colonoscopy Severity of Illness Index Gastroenterology Inflammatory bowel disease Endoscopy Gastrointestinal Feces Leukocyte Count Young Adult Crohn Disease Internal medicine medicine Humans Prospective Studies Colitis Prospective cohort study Aged Crohn's disease medicine.diagnostic_test Norway Platelet Count business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged medicine.disease Ulcerative colitis Anti-Bacterial Agents Diarrhea C-Reactive Protein Colitis Ulcerative Female medicine.symptom Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Scandinavian Journal of Gastroenterology. 46:1081-1091 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | The present population based adult cohort was part of a new prospective study of patients with inflammatory bowel disease (IBD) in South-Eastern Norway, the Inflammatory Bowel South-Eastern Norway II study, investigating disease characteristics in an attempt to improve our knowledge regarding factors related to early clinical phenotype and disease activity.Patients suspected to have IBD on the basis of predefined symptoms, including abdominal pain, diarrhea, and/or blood in stool for more than 10 days were examined at the local hospital. Colonoscopy with biopsies was performed and blood and stool samples were taken.In ulcerative colitis (UC) patients, the median Simple Clinical Colitis Activity Index (SCCAI) was 4 (range 0-10) in mild and 6 (range 0-14) in patients with moderate or severe endoscopic activity of inflammation (p = 0.002). The calprotectin concentration in feces was significantly related to the SCCAI (p = 0.034) and the Mayo endoscopic subscore (p = 0.031). There was a significant association between the C-reactive protein (CRP) value, leucocytes and thrombocytes and the SCCAI, but only leucocytes were significantly associated with the Mayo endoscopic subscore. In Crohn's disease (CD) patients, there was no statistical significant association between the Harvey-Bradshaw Index (HBI) and the endoscopic grade of mucosal inflammation (p = 0.8). The calprotectin concentration in feces was significantly related to the endoscopic activity score (p = 0.004), but not to the HBI (p = 0.5). HBI was significantly related to the CRP value (p = 0.047) and thrombocytes (p = 0.03).In UC, both biochemical and fecal markers are related to disease activity and extent of disease, whereas in CD, the fecal calprotectin concentration is a reliable marker of mucosal affection, but not for systemic disease activity. |
| Databáze: | OpenAIRE |
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