Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample
| Autor: | Nathaniel S. Thomas, Sally I-Chun Kuo, Fazil Aliev, Vivia V. McCutcheon, Jacquelyn M. Meyers, Grace Chan, Victor Hesselbrock, Chella Kamarajan, Sivan Kinreich, John R. Kramer, Samuel Kuperman, Dongbing Lai, Martin H. Plawecki, Bernice Porjesz, Marc A. Schuckit, Danielle M. Dick, Kathleen K. Bucholz, Jessica E. Salvatore |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Psychol Addict Behav |
| ISSN: | 1939-1501 0893-164X |
| Popis: | OBJECTIVE: To examine associations between alcohol use disorder (AUD), its psychiatric comorbidities, and their interactions, with marital outcomes in a diverse high-risk, genetically informative sample. METHOD: Participants included European ancestry (EA, n=4045) and African ancestry (AA, n=1550) individuals from the multigenerational COGA sample (56% female, M(age) ~ 41 years). Outcomes were lifetime marriage and divorce. Predictors included lifetime AUD, an alcohol problems polygenic score, and AUD comorbidities, including antisocial personality disorder (ASP), cannabis dependence/abuse (CAN), frequent tobacco use (TOB), and major depressive disorder (MDD). Mixed effect Cox models and generalized linear mixed effects models were fit. RESULTS: Among EA participants, those with AUD and CAN were less likely to marry (hazard ratios [HR] 0.70–0.83, ps < 0.01). Among AA participants, those with AUD and TOB were less likely to marry (HRs 0.66–0.82, ps < 0.05) and those with MDD were more likely to marry (HR = 1.34, p < 0.01). Among EA participants, AUD, CAN, TOB, and MDD were associated with higher odds of divorce (ORs 1.59–2.21, ps < 0.01). Among AA participants, no predictors were significantly associated with divorce. Significant random effects indicated genetic and environmental influences on marriage, but only environmental factors on divorce. CONCLUSIONS: In a high-risk sample, alcohol use disorder was associated with reduced likelihood of marriage in European and African ancestry individuals, and increased risk of divorce in European ancestry individuals. These associations were largely independent of comorbidities. Genetic and environmental background factors contributed to marriage, while only environmental background factors contributed to divorce. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|