Ocular complications of plasma cell dyscrasias
| Autor: | Rohan Bir Singh, Sachi Singhal, Shruti Sinha, Junsang Cho, Anne Xuan-Lan Nguyen, Lovedeep Singh Dhingra, Snimarjot Kaur, Vasudha Sharma, Aniruddha Agarwal |
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| Rok vydání: | 2023 |
| Předmět: |
corneal degenerations
CORNEA Retinal degenerations associated with systemic disease General Medicine RETINAL ARTERY-OCCLUSION POEMS SYNDROME OPTIC DISK Ophthalmology ORBITAL PLASMACYTOMA EXTRAMEDULLARY PLASMACYTOMA GLAUCOMA PERIPHERAL ULCERATIVE KERATITIS MULTIPLE-MYELOMA WALDENSTROMS MACROGLOBULINEMIA EXTERNAL DISEASE MONOCLONAL GAMMOPATHY NECROBIOTIC XANTHOGRANULOMA RETINA |
| Zdroj: | European Journal of Ophthalmology. :112067212311559 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/11206721231155974 |
| Popis: | Plasma cell dyscrasias are a wide range of severe monoclonal gammopathies caused by pre-malignant or malignant plasma cells that over-secrete an abnormal monoclonal antibody. These disorders are associated with various systemic findings, including ophthalmological disorders. A search of PubMed, EMBASE, Scopus and Cochrane databases was performed in March 2021 to examine evidence pertaining to ocular complications in patients diagnosed with plasma cell dyscrasias. This review outlines the ocular complications associated with smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, plasmacytomas, multiple myeloma, Waldenström's macroglobulinemia, systemic amyloidosis, Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes (POEMS) syndrome, and cryoglobulinemia. Although, the pathological mechanisms are not completely elucidated yet, wide-ranging ocular presentations have been identified over the years, evolving both the anterior and posterior segments of the eye. Moreover, the presenting symptoms also help in early diagnosis in asymptomatic patients. Therefore, it is imperative for the treating ophthalmologist and oncologist to maintain a high clinical suspicion for identifying the ophthalmological signs and diagnosing the underlying disease, preventing its progression through efficacious treatment strategies. |
| Databáze: | OpenAIRE |
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