Long-term outcomes in patients after left atrial appendage occlusion: The results from the LAAO SILESIA registry

Autor: Krzysztof Myrda, Witold Streb, Wojciech Wojakowski, Jacek Piegza, Katarzyna Mitręga, Grzegorz Smolka, Jolanta Nowak, Tomasz Podolecki, Ewa Gasiewska-Żurek, Alicja Nowowiejska-Wiewióra, Malwina Smolarek-Nicpoń, Michał Skrzypek, Mariusz Gąsior, Zbigniew Kalarus
Rok vydání: 2022
Předmět:
Zdroj: Kardiologia Polska. 80:332-338
ISSN: 1897-4279
0022-9032
DOI: 10.33963/kp.a2022.0047
Popis: The benefits of oral anticoagulation (OAC) therapy are undeniable. However, such treatment is contraindicated in 2%-10% of patients. According to the latest guidelines, percutaneous left atrial appendage occlusion (LAAO) may be considered in stroke prevention.We analyzed the data of patients from the Polish population, who had undergone LAAO procedures in the Silesian Province based on limited reports.The data from the SILCARD database of all patients who underwent LAAO between 2006 and 2019, and the data from the databases of the centers performing the procedures in the Silesian Province were included in the LAAO SILESIA registry. We analyzed the efficacy and safety of the procedure and its relationship with the occurrence of stroke and bleeding in the post-hospital follow-up.We analyzed 649 patients with the mean values of CHA2DS2-VASc and HAS-BLED scores of 4.1 and 3.2, respectively. The predominant indication for LAAO was a history of bleeding during OAC. The most frequent in-hospital major adverse cardiac events were anemia, which required blood transfusion (5.5%), and pericardial effusion, which was treated either conservatively (0.9%) or interventionally (1.2%). During hospitalization, stroke was detected in 4 patients and three patients died of any cause. LAAO reduced the annual risk of stroke by 84% and the annual risk of bleeding by 27%.Based on a "real-life" cohort of patients from the Silesian Province, we concluded that LAAO is related to low in-hospital major cardiovascular adverse events. In the long-term follow-up, LAAO reduced the rates of stroke and bleeding.
Databáze: OpenAIRE
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