Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder

Autor: Meriam Messedi, Wassim Guidara, Fatma Ayadi, M. Maalej, Sahar Grayaa, Manel Naifar, Mohamed Maalej, Dominique Bonnefont-Rousselot, Foudil Lamari, Walid Khrouf
Přispěvatelé: Université de Sfax, Université de Sfax - University of Sfax, Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), bigey, pascal
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Tunisia
Oxysterol
27-hydroxycholesterol
Bipolar disorder
Endocrinology
Diabetes and Metabolism
24-hydroxycholesterol
Clinical Biochemistry
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Tandem Mass Spectrometry
Internal medicine
medicine
Humans
Decompensation
Prospective Studies
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Molecular Biology
[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
business.industry
Cholesterol
Cholestanol
Cell Biology
Biomarker
Oxysterols
medicine.disease
Pathophysiology
Hydroxycholesterols
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Case-Control Studies
27-Hydroxycholesterol
Molecular Medicine
Biomarker (medicine)
lipids (amino acids
peptides
and proteins)
sense organs
business
Biomarkers
Chromatography
Liquid
Zdroj: Journal of Steroid Biochemistry and Molecular Biology
Journal of Steroid Biochemistry and Molecular Biology, 2021, 211, pp.105902. ⟨10.1016/j.jsbmb.2021.105902⟩
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2021.105902⟩
Popis: International audience; Cholesterol and its oxygenated metabolites, including oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorders. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders. Recent studies have shown that Bipolar disorder (BD) is associated with the disruption of cholesterol metabolism. The present study was aimed at investigating the profile of oxysterols in plasma, their ratio to total cholesterol and their association with clinical parameters in patients with BD. Thirty three men diagnosed with BD and forty healthy controls matched for age and sex were included in the study. Oxysterol levels were measured by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. Significantly higher levels were observed for cholestane-3β,5α,6β-triol, 27-hydroxycholesterol (27-OHC) and Cholestanol in patients with BD. The concentration of 24-hydroxycholesterol (24-OHC) was significantly lower in patients compared to controls. 24-OHC was also negatively correlated to MAS subscale score (r =-0.343; p = 0.049). In patients, 24-OHC was inversely correlated with age (r = -0.240; p = 0.045). Multivariate analysis found that BD acute decompensation was independently related to the rise in plasma 24-OHC (p = 0.002; OR = 0.966, 95 % CI [0.945 - 0.987]). However, the 24-OHC assay relevance as a biomarker of this disease deserves further investigation in other studies.
Databáze: OpenAIRE
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