Bactericidal effects of high-energy visible light on common otitis media pathogens
| Autor: | Douglas J. Jackson, Rachel Berry, John Naber, Deborah R. Yoder-Himes, Swapna K. Chandran, Shae D. Morgan, Thomas J. Roussel, Elizabeth Cash |
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| Rok vydání: | 2021 |
| Předmět: |
biology
Light Otitis Media with Effusion Therapeutic treatment General Medicine High-energy visible light medicine.disease_cause biology.organism_classification Applied Microbiology and Biotechnology Haemophilus influenzae Microbiology Moraxella catarrhalis Otitis Media Antibiotic resistance Otitis Streptococcus pneumoniae medicine Humans medicine.symptom Bacteria Biotechnology |
| Zdroj: | Journal of applied microbiologyREFERENCES. 132(3) |
| ISSN: | 1365-2672 |
| Popis: | Aims This study assessed the use of high-energy, visible light on the survival rates of three bacteria commonly found in middle ear infections (i.e. otitis media; Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae). Method and Results Bacteria were cultured and then subjected to a single, 4-h treatment of 405 nm wavelength light at two different intensities. All three bacteria species were susceptible to the light at clinically significant rates (>99.9% reduction). Bacteria were susceptible to the high-energy visible (HEV) light in a dose-dependent manner (lower survival rates with increased intensity and duration of exposure). Conclusions The results suggest that HEV light may provide a non-surgical, non-pharmaceutical approach to the therapeutic treatment of otitis media. Significance an Impact of the Study Given the growing concerns surrounding antibiotic resistance, this study demonstrates a rapid, alternative method for effective inactivation of bacterial pathogens partly responsible for instances of otitis media. |
| Databáze: | OpenAIRE |
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