Korean Red Ginseng inhibits methamphetamine addictive behaviors by regulating dopaminergic and NMDAergic system in rodents
| Autor: | Yong-Hyun Ko, Boram Lee, Youyoung Lee, Su-Jeong Sung, Young-Jung Kim, Seok-Yong Lee, Kwang-Hyun Hur, Seong-Eon Kim, Shi-Xun Ma, Seon-Kyung Kim, Choon-Gon Jang |
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| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Korean Red Ginseng Pharmacology Nucleus accumbens Biochemistry Genetics and Molecular Biology (miscellaneous) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopamine receptor D1 Medicine methamphetamine Dopamine transporter biology business.industry Dopaminergic Botany Meth Methamphetamine Conditioned place preference 030104 developmental biology Complementary and alternative medicine chemistry Dopamine receptor drug seeking behavior QK1-989 030220 oncology & carcinogenesis biology.protein N-methyl-D-aspartate receptor dopamine business Research Article Biotechnology medicine.drug |
| Zdroj: | Journal of Ginseng Research, Vol 46, Iss 1, Pp 147-155 (2022) Journal of Ginseng Research |
| ISSN: | 1226-8453 |
| DOI: | 10.1016/j.jgr.2021.05.007 |
| Popis: | Background Methamphetamine (METH) is the most widely used psychostimulant and has been known to exhibit reinforcing effects even after long abstinence. We showed the inhibitory effect of Korean Red Ginseng extract (RGE) on METH-induced addictive behaviors in animal models mimicking the human drug-use pattern. Methods We first investigated the effect of RGE on the acquisition of METH-induced dependence using self-administration and conditioned place preference (CPP) tests. Additionally, further experiments such as METH-induced motivational behavior and seeking behavior were conducted. To study the underlying mechanism, dopamine receptor, dopamine transporter, and N-methyl-D-aspartate receptor were assessed through Western blot analysis. Results Treatment with RGE significantly reduced METH-induced self-administration on a fixed-ratio 1 schedule of reinforcement. It could be also decreased a progressive ratio schedule, and inhibited METH-primed reinstatement. In CPP, RGE significantly prevented the development of METH-induced CPP. Moreover, RGE not only shortened the withdrawal period clearly, but also prevented the reinstatement of CPP. RGE treatment also reversed METH-induced overexpression of dopamine transporter, dopamine receptor D1, and NMDA receptor in the nucleus accumbens. Conclusion Our findings reflect that RGE has therapeutic potential to suppress METH-induced addictive behaviors by regulating dopaminergic and NMDAergic system. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
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