Texture analysis of vertebral bone marrow using chemical shift encoding–based water-fat MRI: a feasibility study
| Autor: | Muthu Rama Krishnan Mookiah, Thomas Baum, Stefan Ruschke, Dennis M. Hedderich, Michael Dieckmeyer, Claus Zimmer, Alexander Rohrmeier, Karupppasamy Subburaj, Ernst J. Rummeny, Egon Burian, Dimitrios C. Karampinos, Maximilian N. Diefenbach, J. S. Kirschke |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Lumbar Body Water Bone Marrow Internal medicine Image Interpretation Computer-Assisted medicine Humans Texture Osteoporosis Postmenopausal Aged Lumbar Vertebrae Postmenopausal women medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Spine Rheumatology ddc Postmenopause medicine.anatomical_structure Adipose Tissue Premenopause Feasibility Studies Female Original Article Lumbar spine 030101 anatomy & morphology Bone marrow business Nuclear medicine Vertebral bone marrow |
| Zdroj: | Osteoporosis International BASE-Bielefeld Academic Search Engine |
| ISSN: | 1433-2965 0937-941X |
| DOI: | 10.1007/s00198-019-04924-9 |
| Popis: | Summary This feasibility study investigated the spatial heterogeneity of the lumbar vertebral bone marrow using chemical shift encoding–based water-fat MRI. Acquired texture features like contrast and dissimilarity allowed for differentiation of pre- and postmenopausal women and may serve as imaging biomarkers in the future. Introduction While the vertebral bone marrow fat using chemical shift encoding water-fat magnetic resonance imaging (MRI) has been extensively studied, its spatial heterogeneity has not been analyzed yet. Therefore, this feasibility study investigated the spatial heterogeneity of the lumbar vertebral bone marrow by using texture analysis in proton density fat fraction (PDFF) maps. Methods Forty-one healthy pre- and postmenopausal women were recruited for this study (premenopausal (n = 15) 30 ± 7 years, postmenopausal (n = 26) 65 ± 7 years). An eight-echo 3D spoiled gradient echo sequence was used for chemical shift encoding–based water-fat separation at the lumbar spine. Vertebral bodies L1 to L5 were manually segmented. Mean PDFF values and texture features were extracted at each vertebral level, namely variance, skewness, and kurtosis, using statistical moments and second-order features (energy, contrast, correlation, homogeneity, dissimilarity, entropy, variance, and sum average). Parameters were compared between pre- and postmenopausal women and vertebral levels. Results PDFF was significantly higher in post- than in premenopausal women (49.37 ± 8.14% versus 27.76 ± 7.30%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink