Quantitative Analysis of Voice in Parkinson Disease Compared to Motor Performance: A Pilot Study
| Autor: | Alice K. Silbergleit, Glendon M. Gardner, Edward L. Peterson, Peter A LeWitt |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Range (music) Activities of daily living Parkinson's disease Pilot Projects Disease Motor Activity Audiology Severity of Illness Index Speech Acoustics Cellular and Molecular Neuroscience Disease severity Severity of illness otorhinolaryngologic diseases medicine Humans Phonation Aged Verbal Behavior Parkinson Disease Middle Aged medicine.disease Waveform analysis Voice Female Neurology (clinical) Psychology |
| Zdroj: | Journal of Parkinson's Disease. 5:517-524 |
| ISSN: | 1877-718X 1877-7171 |
| DOI: | 10.3233/jpd-140526 |
| Popis: | Background Characteristic features of hypokinetic dysarthria develop in Parkinson disease (PD). We hypothesized that quantified acoustic changes of voice might provide a correlate of disease severity. Objective To determine if there are significant differences in acoustic measures of voice between mild and moderate PD; 2) To evaluate correlations between acoustic parameters of voice and subtests of the UPDRS in mild and moderate PD. Methods Twenty six participants with PD underwent vocal acoustic testing while off PD medication, for comparison to 22 healthy controls. Participants with PD were divided into two groups based upon UPDRS activities of daily living (ADL) ratings: summed scores were used to define mild and moderate PD. Participants voiced /i/ ("ee") at comfort, high, and low pitch (3 trials/pitch). The CSpeech Waveform Analysis Program was used to analyze cycle-to-cycle frequency ("jitter") and amplitude ("shimmer") irregularities of the vocal signal, signal-to-noise ratio, and maximum phonation frequency range converted to semitones. Sections of UPDRS scores were correlated to acoustic variables of voice. Results Key findings included a significant difference between the semitone range of the control subjects and the moderate PD group (p = 0.036). Further analyses revealed significant differences in semitone range for males between the controls vs. mild PD (p = 0.014), and controls vs. moderate PD (p = 0.005). Significant correlations were also found between acoustic findings and both the ADL and motor portions of the UPDRS. Conclusions Acoustic analysis of voice, particularly frequency range, may provide a quantifiable correlate of disease progression in PD. |
| Databáze: | OpenAIRE |
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