Human neutrophil lipocalin, a highly specific marker for acute exacerbation in cystic fibrosis
| Autor: | M. Nilsson, I. Enander, D. Y. Koller, R Rath, I Eichler, Per Venge |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Pancreatic disease Adolescent Cystic Fibrosis Exacerbation Neutrophils Lipocalin Sensitivity and Specificity Severity of Illness Index Cystic fibrosis Gastroenterology Lipocalin-2 Proto-Oncogene Proteins Internal medicine medicine Humans Peroxidase Oncogene Proteins biology business.industry Lactoferrin Respiratory disease Acute-phase protein medicine.disease Lipocalins Case-Control Studies Myeloperoxidase Immunology biology.protein Female Carrier Proteins business Biomarkers Acute-Phase Proteins |
| Zdroj: | European Respiratory Journal. 14:1145-1149 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.99.14511459 |
| Popis: | Cystic fibrosis (CF) is characterized by the production of abnormally thick secretions in the airways, chronic bacterial endobronchial infections and a chronic, predominantly neutrophilic inflammatory response. Therefore, myeloperoxidase (MPO) and lactoferrin are frequently used as inflammatory markers. Recently, a new protein in the neutrophil granules, human neutrophil lipocalin (HNL) has been discovered. The aim of the present study was to investigate HNL in sera of patients with CF and its relation to MPO and lactoferrin as well as to acute pulmonary exacerbation. Serum concentrations of HNL, MPO and lactoferrin were determined in 42 patients with CF and in 25 healthy subjects. Patients with CF were divided into groups with and without acute pulmonary exacerbation (APE) and also with and without colonization with Pseudomonas aeruginosa (Pa). Median serum levels of HNL (200.5 microg x L(-1)), MPO (595 microg x L(-1)) and lactoferrin (1,356.5 microg x L(-1)) were significantly increased in patients with CF compared to control subjects (57.7, 178 and 478 microg x L(-1), respectively; p |
| Databáze: | OpenAIRE |
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