Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies
| Autor: | Caifang Gao, Peng Liu, Hongguo Chen, Xu Wu, Xudong Tang, Yitao Wang, Chi Teng Vong, Shengpeng Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
PEI
polyethylenimine medicine.medical_treatment MPO myeloperoxidase Review ICAM intercellular adhesion molecule Inflammatory bowel disease PSGL-1 P-selectin glycoprotein ligand-1 Targeted therapy 0302 clinical medicine Cell adhesion molecule AIE aggregation-induced emission General Pharmacology Toxicology and Pharmaceutics CAM cell adhesion molecule HA hyaluronic acid ACQ aggregation-caused quenching media_common FNII fibronectin type II domain 0303 health sciences Crohn's disease MGL macrophage galactose lectin IBD inflammatory bowel disease Ulcerative colitis CT computed tomography 030220 oncology & carcinogenesis Drug delivery LPS lipopolysaccharide DCs dendritic cells Active target CTLD c-type lectin-like domain MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 Drug media_common.quotation_subject RM1-950 TfR transferrin receptor FRET fluorescence resonance energy transfer ADR adverse drug reaction CS chondroitin sulfate 03 medical and health sciences medicine HUVEC human umbilical vein endothelial cells EPR enhanced permeability and retention CRD cysteine-rich domain 030304 developmental biology MPS mononuclear phagocyte system EGF epidermal growth factor PAMAM poly(amidoamine) business.industry PepT1 peptide transporter 1 GIT gastrointestinal tract QDs quantum dots FR folate receptor Receptor-mediated target medicine.disease MR mannose receptor UC ulcerative colitis Targeted drug delivery Cancer research BSA bovine serum albumin CD Crohn's disease Therapeutics. Pharmacology business LMWC low molecular weight chitosan MRI magnetic resonance imaging RES reticuloendothelial system DSS dextran sulfate sodium salt VCAM vascular cell adhesion molecule |
| Zdroj: | Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2798-2818 (2021) |
| ISSN: | 2211-3843 2211-3835 |
| Popis: | Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization. With no curative therapy for IBD at present, the development of effective therapeutics is highly advocated. Drug delivery systems have been extensively studied to transmit therapeutics to inflamed colon sites through the enhanced permeability and retention (EPR) effect caused by the inflammation. However, the drug still could not achieve effective concentration value that merely utilized on EPR effect and display better therapeutic efficacy in the inflamed region because of nontargeted drug release. Substantial researches have shown that some specific receptors and cell adhesion molecules highly expresses on the surface of colonic endothelial and/or immune cells when IBD occurs, ligand-modified drug delivery systems targeting such receptors and cell adhesion molecules can specifically deliver drug into inflamed sites and obtain great curative effects. This review introduces the overexpressed receptors and cell adhesion molecules in inflamed colon sites and retrospects the drug delivery systems functionalized by related ligands. Finally, challenges and future directions in this field are presented to advance the development of the receptor-mediated targeted drug delivery systems for the therapy of IBD. Graphical abstract When inflammatory bowel disease occurs, some specific receptors and cell adhesion molecules, like mannose receptor, CD98, CD44 and ICAM-1, are overexpressed on the colonic epithelial cells and/or immune cells. Drug delivery systems superficially modified with related ligands can specifically bind to receptors on inflamed cells and deliver drug into target area.Image 1 |
| Databáze: | OpenAIRE |
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