Growth Hormone, Fatigue, Poor Sleep, and Disability in HIV Infection
| Autor: | James C. Miller, Denis F. Darko, Merrill M. Mitler |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Endocrinology Diabetes and Metabolism HIV Infections Electroencephalography Growth hormone Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Humans Disabled Persons Wasting Syndrome Fatigue medicine.diagnostic_test Human Growth Hormone Endocrine and Autonomic Systems business.industry virus diseases Cognition Sleep in non-human animals Growth hormone secretion Poor sleep Immunology Disease Progression Female Tumor necrosis factor alpha business |
| Zdroj: | Neuroendocrinology. 67:317-324 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000054329 |
| Popis: | Poor sleep, daytime fatigue, and loss of cognitive ability exist during all stages of HIV infection, worsening with disease progression. These symptoms contribute to disability and poor quality of life. Data from several research groups support a role of somnogenic inflammatory process peptides elevated in HIV infection, e.g. TNFα. Though the literature is in conflict regarding an effect of HIV infection on growth hormone (GH) secretion, GH axis dysregulation and treatment with GH may be important in HIV infection, e.g. in the wasting syndrome. It has long been known that GH varies with changes in sleep. The hypothesis tested in the current study was that the relationship between delta frequency (0.5–4.0 Hz) sleep EEG amplitude (square root of power from frequency analysis) and GH secretion would differ between HIV positive (HIV+) and HIV negative (HIV–) subjects. In 14 subjects (6 HIV+ and 8 HIV–, none with current or past AIDS-defining illness) a linear relationship change across the night’s sleep was found in the coupling between delta frequency sleep EEG amplitude and GH secretion. The phase coupling change was in opposite directions in HIV+ versus HIV– subjects. This difference supports the hypothesis that the brain-based coordination of sleep and sleep-related physiology deteriorates early in HIV infection, and that GH dysregulation may contribute to this sleep pathology. |
| Databáze: | OpenAIRE |
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