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Objective: The aim of this study is to investigate the possible beneficial effects of brusatol on lung injury caused by cecal ligation and puncture (CLP) model in rats. Methods: In this study, 32 Sprague Dawley male rats were divided into 4 random groups. The groups were programmed as group 1 (sham), group 2 (CLP), group 3 (DMSO), and group 4 (0.5 mg/ml brusatol). In group 1, a midline vertical incision was applied to the abdominal region and closed again without forming a CLP model. Group 2 performed CLP for 18 hours. In group 3, 1% DMSO was administered intraperitoneally 0.3 ml once every two days for 10 days. The last application was made 30 minutes before CLP. In group 4, brusatol was administered intraperitoneally at 0.5 mg/ml once every two days for 10 days. The last application was made 30 minutes before CLP. After CLP was over, the rats were sacrificed and lung tissues were removed. Results: MDA, MPO, OSI, TOS, TNF-? and IL-1? values increased significantly in groups 2 and 3 compared to group 1, while SOD and TAS values decreased. Unlike the increase in antioxidant enzyme activity; MDA level, MPO activity, TOS, OSI, TNF-? and IL-1? values decreased significantly in group 4 compared to groups 2 and 3. Conclusion: As a result, brusatol may play an effective role against CLD-induced lung injury in rats. © 2020. Turk Hij Den Biyol Der. All rights reserved. |
