Low serum adiponectin levels in childhood and adolescence predict increased intima-media thickness in adulthood. The Cardiovascular Risk in Young Finns Study
| Autor: | Leena Taittonen, Risto Huupponen, Jorma Viikari, Terho Lehtimäki, Tomi Laitinen, Liisa Saarikoski, Nina Hutri-Kähönen, Eero Jokinen, Olli T. Raitakari, Markus Juonala |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Adolescent Lipoproteins 030209 endocrinology & metabolism Blood Pressure 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Body Mass Index 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Medicine Humans Risk factor Child Finland ta317 2. Zero hunger Adiponectin business.industry General Medicine Odds ratio ta3121 medicine.disease Endocrinology Carotid Arteries Cross-Sectional Studies Intima-media thickness Cardiovascular Diseases Child Preschool Cardiology Population study Female Metabolic syndrome business Body mass index Cohort study |
| Zdroj: | Annals of Medicine. 49(1):42-50 |
| ISSN: | 0785-3890 |
| Popis: | Low adiponectin levels may predict the development of atherosclerosis. We examined the association of childhood adiponectin with preclinical carotid atherosclerosis that is defined as plaque and/or high (≥95th percentile) intima-media thickness (IMT) at the carotid bifurcation in adulthood.The Cardiovascular Risk in Young Finns Study is a cohort study on cardiovascular risk factors. We used risk factor data from the baseline study (1980) and ultrasound findings from the follow-ups (2001 and 2007). The study population included 1708 participants, aged 3-18 years at baseline.In multivariate analysis, childhood adiponectin was inversely associated with preclinical carotid atherosclerosis: odds ratio 0.68, 95% confidence interval (CI) 0.53-0.86, p = .001, for 1-SD increase in childhood adiponectin after adjusting for childhood non-high-density lipoprotein cholesterol, body mass index, and blood pressure. When examining the incremental predictive ability, we observed that compared to an approach utilizing only conventional risk factors, the model additionally including adiponectin levels improved c-statistics area under curve from 0.733 (95% Cl 0.694-0.771) to 0.748 (95% Cl 0.710-0.786), p = .02.Childhood adiponectin levels improve the prediction of carotid atherosclerosis in adulthood over conventional risk factors. This supports the idea that low adiponectin levels may have a role in the development of preclinical atherosclerosis. Key messages Childhood adiponectin levels improve the prediction of increased carotid intima-media thickness in adulthood over conventional cardiovascular risk factors. These results suggest that adiponectin levels measured in childhood may have a role in the atherosclerotic process. |
| Databáze: | OpenAIRE |
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