Anti-fatigue, highly resilient photocrosslinkable gellan gum hydrogels reinforced by flexible nanoparticulate polyurethane multi-crosslinkers
| Autor: | Payam Baei, Hamed Daemi, Maryam Sahraro, Mehdi Barikani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Cell Survival Polyurethanes Nanoparticle 02 engineering and technology Methacrylate Biochemistry 03 medical and health sciences chemistry.chemical_compound Fatigue resistance Structural Biology Humans Molecular Biology Cells Cultured 030304 developmental biology Polyurethane 0303 health sciences Tissue Engineering Nanocomposite hydrogels Polysaccharides Bacterial Green Chemistry Technology Hydrogels Hydrogen Bonding General Medicine Fibroblasts 021001 nanoscience & nanotechnology Dynamic Light Scattering Gellan gum Compressive strength chemistry Chemical engineering Self-healing hydrogels Methacrylates 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 183:831-838 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2021.04.144 |
| Popis: | In this study, multifunctional polyurethane nanoparticles (MPUNs) were embedded into the methacrylated gellan gum (MGG) to prepare stimuli-responsive hydrogels with improved mechanical properties including remarkable fatigue resistance and excellent self-recoverability. The photocurable MPUNs/MGG nanocomposite hydrogels with different formulations were synthesized through a facile and green solution mixing method. The result obtained from mechanical analysis displayed an excellent improvement in compression strength (120 6 ± 83.7 kPa) and ultimate strain (94.2 ± 2.7%) in the optimized formulation. Furthermore, the optimized formulation could restore approximately its original shape after continuous loading-unloading compression tests over 100 cycles which might result from its favorable crosslinked structure. These reinforced hydrogels exhibited a dual physical and chemical crosslinking mechanism based on the hydrogen bonding formation and photocrosslinking of methacrylate functional groups, respectively. Interestingly, the nanocomposite hydrogels exhibited no significant cytotoxicity to human dermal fibroblast cells which made them suitable as the appropriate biomaterials for the engineering of soft tissues. |
| Databáze: | OpenAIRE |
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