Main-Chain Polysulfonium Salts: Development of Non-Ammonium Antibacterial Polymers Similar in Their Activity to Antibiotic Drugs Vancomycin and Kanamycin
| Autor: | Junki Oh, Anzar Khan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Polymers Sulfonium Bioengineering Context (language use) Microbial Sensitivity Tests medicine.disease_cause Biomaterials chemistry.chemical_compound Kanamycin Vancomycin Ammonium Compounds Materials Chemistry medicine Escherichia coli biology Chemistry Mycobacterium smegmatis biology.organism_classification Combinatorial chemistry Polyelectrolyte Anti-Bacterial Agents Pharmaceutical Preparations Salts Antibacterial activity Bacteria medicine.drug |
| Zdroj: | Biomacromolecules. 22:3534-3542 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.1c00627 |
| Popis: | Typically, quaternary ammonium polymers are employed for antibacterial purposes. However, a century of use has led bacteria to develop resistance to such materials. Therefore, attention is now turning toward other cationic moieties. In this context, the present work explores sulfur-based main-chain cationic polymers. The results indicate that sulfonium polymers with a β-hydroxy motif do not suffer from structural instability issues as is commonly observed in cationic polythioethers. Furthermore, they can be highly effective toward important Gram-positive bacterial strains such as Mycobacterium smegmatis, a model organism to develop drugs against rapidly spreading tuberculosis infections. More importantly, however, more challenging Gram-negative strains such as Escherichia coli can also be targeted by the polysulfoniums with equal effectiveness. Interestingly, side-chain sulfonium polyelectrolytes are observed to be devoid of any significant antibacterial activity. Finally, a comparison with kanamycin and vancomycin suggests the present polymers to be similarly effective as the bactericidal antibiotic drugs. Overall, these results indicate the effectiveness of the main-chain trivalent β-hydroxy sulfonium motif for the development of novel antibacterial polymers with a non-ammonium structure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|