IL-27, a pleiotropic cytokine for fine-tuning the immune response in cancer
| Autor: | Mahshid Zohouri, Morvarid Asadipour, Zahra Beizavi, Abbas Ghaderi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Interleukin-27 medicine.medical_treatment T cell Immunology Biology Lymphocyte Activation Natural killer cell 03 medical and health sciences 0302 clinical medicine Immune system Neoplasms medicine Immunology and Allergy Cytotoxic T cell Macrophage Humans Interleukins Dendritic cell Immunotherapy 030104 developmental biology medicine.anatomical_structure Cytokine Cancer research Cytokines 030215 immunology |
| Zdroj: | International reviews of immunology. 40(5) |
| ISSN: | 1563-5244 |
| Popis: | Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in modulating inflammation in partnership with innate and adaptive immune cells. IL-27 binding to IL-27R starts downstream signaling based on the target cells. It can instigate inflammation by inducing CD4+ T cell proliferation, Th1 polarization, cytotoxic T cell activation, generation of the natural killer cell, and macrophage and dendritic cell activation. However, by inducing programmed cell death and suppression of effector cells, IL-27 can suppress inflammation and return the immune response to hemostasis. Altogether, IL-27 displays multifaceted dual functions, which may result in either pro- or anti-inflammatory effects. Recent investigations indicated the antitumor activity of IL-27 via inducing Th1, and CTL responses and generating NK cells. On the other hand, IL-27 also can promote tumor cells' proliferation, survival, and angiogenesis. In the present review, we'll discuss recent advances concerning the role of IL-27 in inflammatory diseases such as infections, autoimmune diseases with a focus on cancer. |
| Databáze: | OpenAIRE |
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