Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water

Autor: Jyoti Singh, Daniel Whitaker, Benjamin Thoma, Saidul Islam, Callum S. Foden, Abil E. Aliev, Tom D. Sheppard, Matthew W. Powner
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American Chemical Society. 144:10151-10155
ISSN: 1520-5126
0002-7863
DOI: 10.1021/jacs.2c03486
Popis: The prebiotic origin of catalyst-controlled peptide synthesis is fundamental to understanding the emergence of life. Building on our recent discovery that thiols catalyze the ligation of amino acids, amides, and peptides with amidonitriles in neutral water, we demonstrate the outcome of ligation depends on pH and that high p
Databáze: OpenAIRE