Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water
Autor: | Jyoti Singh, Daniel Whitaker, Benjamin Thoma, Saidul Islam, Callum S. Foden, Abil E. Aliev, Tom D. Sheppard, Matthew W. Powner |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Journal of the American Chemical Society. 144:10151-10155 |
ISSN: | 1520-5126 0002-7863 |
DOI: | 10.1021/jacs.2c03486 |
Popis: | The prebiotic origin of catalyst-controlled peptide synthesis is fundamental to understanding the emergence of life. Building on our recent discovery that thiols catalyze the ligation of amino acids, amides, and peptides with amidonitriles in neutral water, we demonstrate the outcome of ligation depends on pH and that high p |
Databáze: | OpenAIRE |
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