Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders
| Autor: | Brian A. Gray, Dennis B. Cornfield, Angela Bent-Williams, Robert Zori |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cancer Research
medicine.medical_specialty Chromosomes Human Pair 20 Chromosomal translocation Chromosomal rearrangement Biology Translocation Genetic hemic and lymphatic diseases Genetics medicine Humans Molecular Biology Polycythemia Vera X chromosome In Situ Hybridization Fluorescence Aged Aged 80 and over Chromosomes Human X medicine.diagnostic_test Cytogenetics Chromosome Middle Aged medicine.disease Molecular biology Leukemia Myeloid Acute Myelodysplastic Syndromes Chromosome abnormality Female Chromosome 20 Fluorescence in situ hybridization |
| Zdroj: | Cancer genetics and cytogenetics. 141(2) |
| ISSN: | 0165-4608 |
| Popis: | Reports of X chromosome translocations, as primary chromosomal changes associated with hematologic disorders, remain relatively uncommon. Herein, we report the detection, by conventional cytogenetic methods, of a cytogenetically identical t(X;20) in two different patients with hematologic disorders (probable myelodysplasia and polycythemia vera/acute myelocytic leukemia). In both cases, this translocation appeared as the primary clonal chromosome abnormality, with breakpoints occurring in the long arms of both the X chromosome and chromosome 20 (Xq13.1 and 20q13.3, respectively). Further characterization and comparison of the translocation chromosome products of these two cases by use of fluorescence in situ hybridization techniques is also described. Similar previously reported cytogenetically cases and the potential that this specific rearrangement may represent a nonrandom chromosomal finding are discussed. |
| Databáze: | OpenAIRE |
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