Ethylene oxide allergy in children with spina bifida
| Autor: | George F. Steinhardt, Jean Kiburz, Jeremy Krock, Keith Gabriel, Thomas Pittman |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Ethylene Oxide
Allergy medicine.medical_specialty Adolescent Latex Immunology Immunoglobulin E Antibodies Drug Hypersensitivity Reference Values Immunopathology Internal medicine medicine Humans Immunology and Allergy Child Spinal Dysraphism biology business.industry Spina bifida Infant medicine.disease El Niño Child Preschool biology.protein Population study Antibody business Anaphylaxis |
| Zdroj: | Journal of Allergy and Clinical Immunology. 96:486-488 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/s0091-6749(95)70291-1 |
| Popis: | Allergic reactions to ethylene oxide (EtO-treated products have occurred in several children with myelomeningoceles.The object of this study was to define the prevalence and significance of EtO-specific IgE among the children in our myelomeningocele clinic.The study population comprised three groups: children clinic.The study population comprised three groups: children with myelomeningoceles, chronically ill controls (defined as children who had undergone at least three major operations), and well-child controls. Serum specimens were collected from each child, and a commercially available ELISA designed to identify IgE directed against both EtO and latex was performed on the specimens.Seventeen of 75 (23%) children with myelomeningoceles had antibodies directed against EtO, as did 1 of 26 (4%) chronically ill controls. None of the 25 well controls had detectable levels of anti-EtO IgE. Children with antibodies directed against EtO were more likely to be atopic (p = 0.007) and to have a shunt (p = 0.021) and were markedly more likely to have antibodies directed against latex (p = 0.001). On average they had undergone more shunt revisions and other operations than had children without anti-EtO antibodies.During the period of study no child had anaphylaxis thought to have been due to EtO exposure. |
| Databáze: | OpenAIRE |
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