Effects of patterned peripheral nerve stimulation on soleus spinal motor neuron excitability

Autor: Tomás Gallego-Izquierdo, Carmen Carrasco-Lopez, Michele Dileone, Antonio Oliviero, Fabricia Moitinho-Ferreira, Josep Valls-Solé, Juan Aguilar, Samuel Jimenez, Laura Mordillo-Mateos, Hartwig R. Siebner, Michela Campolo
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Flexor carpi radialis muscle
lcsh:Medicine
Stimulation
Nervous System
Median Nerve/physiology
Tibial Nerve/physiology
H-Reflex
0302 clinical medicine
Reflexes
Medicine and Health Sciences
Muscle
Skeletal/innervation
lcsh:Science
Tibial nerve
Musculoskeletal System
Spinal Cord/cytology
Motor Neurons
Multidisciplinary
Nerves
Depression
Muscles
Middle Aged
medicine.anatomical_structure
Bioassays and Physiological Analysis
Spinal Cord
Transcutaneous Electric Nerve Stimulation
Female
Anatomy
Muscle Electrophysiology
Research Article
Adult
Surgical and Invasive Medical Procedures
Research and Analysis Methods
03 medical and health sciences
Young Adult
Mental Health and Psychiatry
medicine
Functional electrical stimulation
Humans
Muscle
Skeletal
Transcutaneous Electric Nerve Stimulation/methods
Soleus muscle
Functional Electrical Stimulation
business.industry
Mood Disorders
Electromyography
lcsh:R
Electrophysiological Techniques
Biology and Life Sciences
Soleus Muscles
Motor neuron
Spinal cord
Median Nerve
Neuroanatomy
030104 developmental biology
Spinal Nerves
Motor Neurons/physiology
lcsh:Q
H-reflex
Tibial Nerve
business
Neuroscience
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192471 (2018)
Jimenez, S, Mordillo-Mateos, L, Dileone, M, Campolo, M, Carrasco-Lopez, C, Moitinho-Ferreira, F, Gallego-Izquierdo, T, Siebner, H R, Valls-Solé, J, Aguilar, J & Oliviero, A 2018, ' Effects of patterned peripheral nerve stimulation on soleus spinal motor neuron excitability ', PLoS ONE, vol. 13, no. 2, e0192471 . https://doi.org/10.1371/journal.pone.0192471
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0192471
Popis: Spinal plasticity is thought to contribute to sensorimotor recovery of limb function in several neurological disorders and can be experimentally induced in animals and humans using different stimulation protocols. In healthy individuals, electrical continuous Theta Burst Stimulation (TBS) of the median nerve has been shown to change spinal motoneuron excitability in the cervical spinal cord as indexed by a change in mean H-reflex amplitude in the flexor carpi radialis muscle. It is unknown whether continuous TBS of a peripheral nerve can also shift motoneuron excitability in the lower limb. In 26 healthy subjects, we examined the effects of electrical TBS given to the tibial nerve in the popliteal fossa on the excitability of lumbar spinal motoneurons as measured by H-reflex amplitude of the soleus muscle evoked by tibial nerve stimulation. Continuous TBS was given at 110% of H-reflex threshold intensity and compared to non-patterned regular electrical stimulation at 15 Hz. To disclose any pain-induced effects, we also tested the effects of TBS at individual sensory threshold. Moreover, in a subgroup of subjects we evaluated paired-pulse inhibition of H-reflex. Continuous TBS at 110% of H-reflex threshold intensity induced a short-term reduction of H-reflex amplitude. The other stimulation conditions produced no after effects. Paired-pulse H-reflex inhibition was not modulated by continuous TBS or non-patterned repetitive stimulation at 15 Hz. An effect of pain on the results obtained was discarded, since non-patterned 15 Hz stimulation at 110% HT led to pain scores similar to those induced by EcTBS at 110% HT, but was not able to induce any modulation of the H reflex amplitude. Together, the results provide first time evidence that peripheral continuous TBS induces a short-lasting change in the excitability of spinal motoneurons in lower limb circuitries. Future studies need to investigate how the TBS protocol can be optimized to produce a larger and longer effect on spinal cord physiology and whether this might be a useful intervention in patients with excessive excitability of the spinal motorneurons.
Databáze: OpenAIRE
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