The Efficacy and Biopharmaceutical Properties of a Fixed-Dose Combination of Disulfiram and Benzyl Benzoate
| Autor: | Maria Lajarin-Reinares, Elia Martinez-Esteve, Eloy Pena-Rodríguez, Mariona Cañellas-Santos, Sanja Bulut, Kostas Karabelas, Adam Clauss, Carles Nieto, Mireia Mallandrich, Francisco Fernandez-Campos |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Insecticides Benzyl benzoate benzyl benzoate skin permeation Medicació transdèrmica Infections Benzoates Catalysis Inorganic Chemistry Scabies Topical medication Disulfiram Animals Humans Physical and Theoretical Chemistry Antiparasitic agents Molecular Biology Permethrin Spectroscopy Skin permeation Biological Products Sheep Organic Chemistry Pediculus General Medicine Lice Infestations lice Transdermal medication Infeccions Computer Science Applications Ronya Malathion antiparasitic agents Emulsions topical medication Lice |
| Zdroj: | International Journal of Molecular Sciences Volume 23 Issue 18 Pages: 10969 |
| Popis: | Scabies and hair lice are parasitic diseases that affect human skin and hair, respectively. The incidence and resistances of these infections are increasing. Tenutex® (disulfiram and benzyl benzoate emulsion) is an alternative to standard insecticides to avoid resistances. The aim of the work is to evaluate the transdermal absorption and the in vitro efficacy against scabies and hair lice after different exposition times. Dermatomed human skin was used to assess the dermal absorption using a validated High Performance Liquid Chromatography (HPLC) method. HEK001 keratinocytes were used to evaluate the cytotoxicity of benzyl benzoate. Only benzyl benzoate was able to cross the skin, but it did not show cytotoxicity at any of the tested concentrations. The product efficacy was tested on Psoroptes ovis after direct contact and after administration on sheep skin explants at different contact times. Permethrin/malathion-resistant strains of Pediculus humanis capitis adults and eggs were directly exposed to Tenutex, and the vitality and hatchability, respectively, were evaluated. The anti-scabies study demonstrated that exposure for 6 or 24 h completely eradicated the parasite. The pediculicidal activity of Tenutex exhibited superior efficacy than standard treatment on resistant lice. The positive results obtained suggest that Tenutex® is a good treatment option, especially in drug resistance situations. |
| Databáze: | OpenAIRE |
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