Skin IL-17-Producing T Cells Support Repair 2!
| Autor: | Gretchen E. Diehl, Daniel F. Zegarra-Ruiz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Receptors Antigen T-Cell Biology Mice 03 medical and health sciences Th2 Cells 0302 clinical medicine Antigen Immunity Tissue damage medicine Animals Humans Immunology and Allergy Receptor Immunity Cellular Wound Healing Microbiota T-cell receptor Nuclear Receptor Subfamily 1 Group F Member 3 Cell biology 030104 developmental biology Cytokine Cytokines Interleukin 17 Wound healing 030215 immunology |
| Zdroj: | Trends in Immunology. 40:177-179 |
| ISSN: | 1471-4906 |
| DOI: | 10.1016/j.it.2019.01.004 |
| Popis: | In a recent study, Harrison et al. (Science 2019;363;eaat6280) report that RORγt-expressing skin commensal-specific T cells rapidly respond to tissue wounding by producing type 2 T helper cell (Th2) cytokines in mice. The cells constitutively coexpress GATA-3 and type 2 cytokine mRNAs that are translated after injury. These T cells act as sentinels, linking T cell receptor (TCR) recognition of commensals, tissue damage, and wound repair. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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