Dietary Intake is Associated with miR-31 and miR-375 Expression in Patients with Head and Neck Squamous Cell Carcinoma
| Autor: | Eneida Franco Vêncio, Antônio Paulo Machado Gontijo, Ana Flávia Mendes Griebeler, Larissa Morinaga Matida, Alexandre Siqueira Guedes Coelho, Maria Aderuza Horst, Cristiane Cominetti, Ana Carolina da Silva Lima, Tathiany Jéssica Ferreira, Caroline Castro de Araújo |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
Cancer Research Medicine (miscellaneous) Ascorbic Acid Eating chemistry.chemical_compound Mir-375 Cell Line Tumor Vitamin D and neurology Humans Medicine Vitamin B12 Nutrition and Dietetics Vitamin C Squamous Cell Carcinoma of Head and Neck business.industry Vitamins Oncomir medicine.disease Head and neck squamous-cell carcinoma Gene Expression Regulation Neoplastic mir-31 MicroRNAs Oncology chemistry Head and Neck Neoplasms Carcinoma Squamous Cell Cancer research Sugars business |
| Zdroj: | Nutrition and Cancer. 74:2049-2058 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. Nutrients are known to influence miRNA expression; however, this association is poorly explored in HNSCC. This work aimed to identify associations between dietary intake and the expression of miR-31 and miR-375 in patients newly diagnosed with HNSCC. The expression of miR-31 was positively associated with the consumption of iron (β = 16.65) and vitamin C (β = 0.37), and inversely associated with total sugar (β = -0.88), cholesterol (β= -0.23), vitamin B9 (β= -0.37) and zinc (β = -5.66) intake. The expression of miR-375 was positively associated with the consumption of selenium (β = 1.52), vitamin C (β = 0.17) and vitamin D (β = 13.01), and inversely associated with the consumption of added sugar (β = -0.49), phosphorus (β= -0.27) and vitamin B12 (β = -10.80). Our findings showed important associations between dietary intake and miR-31 and miR-375 expression in HNSCC, offering possible directions for further studies investigating how nutrients interfere with carcinogenesis.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1990972 . |
| Databáze: | OpenAIRE |
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