Statins in Asthma: A Closer Look into the Pharmacological Mechanism of Action
| Autor: | Nour A. Al-Sawalha, Brian J. Knoll |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell signaling Chemokine Myocytes Smooth Muscle Inflammation Pharmacology 03 medical and health sciences 0302 clinical medicine In vivo Animals Humans Medicine Asthma Clinical Trials as Topic biology business.industry General Medicine respiratory system medicine.disease respiratory tract diseases Clinical trial 030104 developmental biology 030228 respiratory system Mechanism of action Immunology biology.protein Airway Remodeling Bronchial Hyperreactivity Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom business Airway |
| Zdroj: | Pharmacology. 98:279-283 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000449062 |
| Popis: | The effect of stains in asthma is mediated through targeting several signaling molecules that are involved in the development of asthma phenotype. In vitro and in vivo studies revealed that statins reduce airway smooth muscle cells proliferation and inflammatory mediators' release. Statins reduce chemokine release and mucus production from airway epithelial cells besides attenuating subepithelial fibrosis and eosinophils recruitment. In acute and chronic allergen driven animal models of asthma, statins reduce airway hyper-responsiveness, inflammation and remodeling. However, the effectiveness of statins in clinical trials results in contradictory conclusions based on study design and treatment protocol. Therefore, more clinical trials are needed to evaluate their role in asthma patients. |
| Databáze: | OpenAIRE |
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