Neuromyelitis optica and aquaporin-4 (AQP4) autoantibodies in consecutive optic neuritis patients in Southern Finland
| Autor: | Tero Kivelä, Mika Siuko, Sari Atula, Aaro Miettinen, Kari-Pekka Saastamoinen, Pentti J. Tienari, Kirsi Setälä |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Radioimmunoprecipitation Assay Optic Neuritis Adolescent Population Enzyme-Linked Immunosorbent Assay Gastroenterology Autoantigens Young Adult Internal medicine medicine Humans Optic neuritis Risk factor education Finland Autoantibodies Aquaporin 4 education.field_of_study Neuromyelitis optica business.industry Multiple sclerosis Neuromyelitis Optica Autoantibody General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging 3. Good health Ophthalmology Cohort Female business |
| Zdroj: | Acta ophthalmologica. 92(4) |
| ISSN: | 1755-3768 |
| Popis: | Purpose: To analyse the frequency of neuromyelitis optica (NMO) among consecutive optic neuritis (ON) patients in Southern Finland and the feasibility of Aquaporin-4 (AQP4) autoantibody assay in the diagnosis of NMO. Methods: Consecutive patients with symptoms suggestive of acute ON and managed in the Helsinki University Central Hospital were evaluated critically screened for AQP4 autoantibody during a 47.5-month period. The antibodies were determined using radioimmunoprecipitation method. AQP4 index >15 was considered positive, 10–15 borderline and |
| Databáze: | OpenAIRE |
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