Comparison of diamond-like carbon-coated nitinol stents with or without polyethylene glycol grafting and uncoated nitinol stents in a canine iliac artery model
| Autor: | Jong Hoon Kim, Moon Mw, Kyung Min Shin, Tae Hyun Kim, Kwang-Ryeol Lee, Shin Dh, Won Yh, Kwideok Park, Dong Keun Han, Ji Hoon Shin |
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| Rok vydání: | 2011 |
| Předmět: |
Nitinol stent
medicine.medical_specialty medicine.medical_treatment Polyethylene glycol Iliac Artery Polyethylene Glycols chemistry.chemical_compound Blood Vessel Prosthesis Implantation Dogs Restenosis Coated Materials Biocompatible Neointima Occlusion medicine Alloys Animals Radiology Nuclear Medicine and imaging cardiovascular diseases Neointimal hyperplasia Iliac artery Hyperplasia Full Paper business.industry Stent General Medicine equipment and supplies medicine.disease Thrombosis Surgery surgical procedures operative chemistry Stents business |
| Zdroj: | The British journal of radiology. 84(999) |
| ISSN: | 1748-880X |
| Popis: | Objective: Neointimal hyperplasia is a major complication of endovascular stent placement with consequent in-stent restenosis or occlusion. Improvements in the biocompatibility of stent designs could reduce stent-associated thrombosis and in-stent restenosis. We hypothesised that the use of a diamond-like carbon (DLC)-coated nitinol stent or a polyethylene glycol (PEG)-DLC-coated nitinol stent could reduce the formation of neointimal hyperplasia, thereby improving stent patency with improved biocompatibility. Methods: A total of 24 stents were implanted, under general anaesthesia, into the iliac arteries of six dogs (four stents in each dog) using the carotid artery approach. The experimental study dogs were divided into three groups: the uncoated nitinol stent group (n58), the DLC-nitinol stent group (n58) and the PEG-DLC-nitinol stent group (n58). Results: The mean percentage of neointimal hyperplasia was significantly less in the DLC-nitinol stent group (26.7i7.6%) than in the nitinol stent group (40.0i20.3%) (p50.021). However, the mean percentage of neointimal hyperplasia was significantly greater in the PEG-DLC-nitinol stent group (58.7i24.7%) than in the nitinol stent group (40.0i20.3%) (p50.01). Conclusion: Our findings indicate that DLC-coated nitinol stents might induce less neointimal hyperplasia than conventional nitinol stents following implantation in a canine iliac artery model; however, the DLC-coated nitinol stent surface when reformed with PEG induces more neointimal hyperplasia than either a conventional or DLCcoated nitinol stent. |
| Databáze: | OpenAIRE |
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