Tumor doubling time and local immune response to hepatic metastases from colorectal cancer
| Autor: | Masatoshi Nakazawa, Ayako Kito, Mutsuhiko Minami, Kuniya Tanaka, Hiroshi Shimada, Shinji Togo, Haruka Fujimaki |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
Male medicine.medical_specialty Colorectal cancer Immunoglobulins Tumor M2-PK Metastasis Immune system Lymphocytes Tumor-Infiltrating Antigen Antigens CD Internal medicine Proliferating Cell Nuclear Antigen medicine Humans Aged Cell Proliferation Membrane Glycoproteins Tumor-infiltrating lymphocytes business.industry Liver Neoplasms Cancer General Medicine Dendritic cell Dendritic Cells Middle Aged medicine.disease Ki-67 Antigen Cancer research Surgery Female business Colorectal Neoplasms |
| Zdroj: | Journal of surgical oncology. 96(6) |
| ISSN: | 0022-4790 |
| Popis: | Background and objectives A number of studies have investigated the role of tumor-infiltrating lymphocytes in cancer, yet the local immune response to hepatic colorectal cancer metastasis remains unclear. As the tumor doubling time (DT) of hepatic colorectal cancer metastases is a good index of tumor growth, we examined the correlation between tumor DT and the local immune response by phenotype in hepatic colorectal cancer metastases. Methods Tumor DT and local immune response were examined in 20 patients with hepatic colorectal cancer metastases by analyzing tumor-infiltrating lymphocytes using flow cytometry or immunohistochemical studies. Tumor proliferative activity was also investigated by determining the expression levels of Ki-67 and proliferating cell nuclear antigen (PCNA). Results Locally abundant populations of CD83+ dendritic cells (DCs) and CD8+ T cells were positively related to longer tumor DT (P |
| Databáze: | OpenAIRE |
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