Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment
| Autor: | Norbert Gyöngyösi, Zita Kátai, Gyorgy Bagdy, Brigitta Balogh, Kornélia Tekes, Eszter Molnár, Rudolf Laufer |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
Male medicine.medical_specialty Time Factors medicine.drug_class N-Methyl-3 4-methylenedioxyamphetamine Polysomnography Ecstasy Biguanides Electroencephalography Motor Activity Hippocampus 5-HT3 receptor Random Allocation Serotonin Agents Internal medicine medicine Animals Theta Rhythm Wakefulness Biological Psychiatry 5-HT receptor Slow-wave sleep biology medicine.diagnostic_test Chemistry Brain MDMA Serotonin 5-HT3 Receptor Agonists Circadian Rhythm Rats Serotonin Receptor Agonists Psychiatry and Mental health Endocrinology Neurology Anesthesia biology.protein Neurology (clinical) Serotonin Sleep Stages Receptors Serotonin 5-HT3 Sleep psychological phenomena and processes medicine.drug |
| Zdroj: | Journal of neural transmission (Vienna, Austria : 1996). 117(3) |
| ISSN: | 1435-1463 |
| Popis: | The recreational drug "Ecstasy" [3,4-methylenedioxymethamphetamine (MDMA)] has a well-characterised neurotoxic effect on the 5-hydroxytryptamine (5-HT) neurons in animals. Despite intensive studies, the long-term functional consequencies of the 5-HT neurodegeneration remains elusive. The aim of this study was to investigate whether any alteration of 5-hydroxytryptamine-3 (5-HT(3)) receptor functions on the sleep-wake cycle, motor activity, and quantitative EEG could be detected 6 months after a single dose of 15 mg/kg of MDMA. The selective 5-HT(3) receptor agonist m-chlorophenylbiguanide (mCPBG; 1 mg/kg, i.p.) or vehicle was administered to freely moving rats pre-treated with MDMA (15 mg/kg, i.p.) or vehicle 6 months earlier. Polysomnographic and motor activity recordings were performed. Active wake (AW), passive wake (PW), light slow wave sleep (SWS-1), deep slow wave sleep (SWS-2), and paradoxical sleep were classified. In addition, EEG power spectra were calculated for the second hour after mCPBG treatment for each stage. AW increased and SWS-1 decreased in the second hour after mCPBG treatment in control animals. mCPBG caused significant changes in the EEG power in states with cortical activation (AW, PW, paradoxical sleep). In addition, mCPBG had a biphasic effect on hippocampal theta power in AW with a decrease in 7 Hz and a stage-selective increase in the upper range (8-9 Hz). Effects of mCPBG on the time spent in AW and SWS-1 were eliminated or reduced in MDMA-treated animals. In addition, mCPBG did not increase the upper theta power of AW in rats pre-treated with MDMA. These data suggest long-term changes in 5-HT(3) receptor function after MDMA. |
| Databáze: | OpenAIRE |
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