Trifluoromethylation of α-Haloketones
| Autor: | Vladimir V. Grushin, Petr Novák, Anton Lishchynskyi |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of the American Chemical Society. 134:16167-16170 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja307783w |
| Popis: | The C-X bond (X = Br, Cl) of α-haloketones is smoothly trifluoromethylated with the fluoroform-derived CuCF(3) reagent recently developed in our laboratories. This is the first nucleophilic α-trifluoromethylation reaction of carbonyl compounds and a rare example of CF(3)-C(sp(3)) coupling. The transformation employs only low-cost chemicals and cleanly occurs in up to 99% yield at room temperature, thereby providing an unprecedentedly easy entry to valuable 2,2,2-trifluoroethylketones. |
| Databáze: | OpenAIRE |
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