Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels

Autor: Kaidi Mikhitarian, Frank Revetta, Maressa Pollen, Chanjuan Shi, M. Kay Washington, Alexander A. Parikh, Zhiguo Zhao, Yu Shyr, Nipun B. Merchant, Cindy L. Vnencak-Jones
Rok vydání: 2014
Předmět:
Male
Proto-Oncogene Proteins B-raf
Ampulla of Vater
Pathology
medicine.medical_specialty
Class I Phosphatidylinositol 3-Kinases
Common Bile Duct Neoplasms
DNA Mutational Analysis
AKT1
Adenocarcinoma
medicine.disease_cause
Article
Pathology and Forensic Medicine
Phosphatidylinositol 3-Kinases
03 medical and health sciences
0302 clinical medicine
Amphiregulin
Duodenal Neoplasms
medicine
Humans
PTEN
Epidermal growth factor receptor
neoplasms
Aged
030304 developmental biology
0303 health sciences
Epidermal growth factor receptor pathway
Ampullary carcinoma
biology
PTEN Phosphohydrolase
Middle Aged
medicine.disease
3. Good health
ErbB Receptors
Pancreatic Neoplasms
030220 oncology & carcinogenesis
ras Proteins
biology.protein
Cancer research
Immunohistochemistry
Female
KRAS
Signal transduction
Proto-Oncogene Proteins c-akt
Signal Transduction
Zdroj: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
ISSN: 0893-3952
DOI: 10.1038/modpathol.2013.185
Popis: Our objective was to explore alteration of the epidermal growth factor receptor signaling pathway in ampullary carcinoma. Immunohistochemical studies were employed to evaluate expression of amphiregulin as well as expression and activation of epidermal growth factor receptor. A lab developed assay was used to identify mutations in the epidermal growth factor receptor pathway genes, including KRAS, BRAF, PIK3CA, PTEN and AKT1. Fifty two ampullary carcinomas were identified, including 25 intestinal-type and 24 pancreatobiliary-type tumors with the intestinal type being associated with a younger age at diagnosis (p=0.03) and a better prognosis (p
Databáze: OpenAIRE
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