Effects of post-partum administration of ketoprofen on sow health and piglet growth
| Autor: | Marja Raekallio, Elina Viitasaari, Laura Hänninen, Olli Peltoniemi, Toomas Orro, Anna Valros, Mari Heinonen |
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| Přispěvatelé: | Departments of Faculty of Veterinary Medicine, Production Animal Medicine, Equine and Small Animal Medicine, Research Centre for Animal Welfare, Animal Reproduction Science, Teachers' Academy |
| Rok vydání: | 2013 |
| Předmět: |
Ketoprofen
Shoulder 040301 veterinary sciences Swine medicine.medical_treatment Sus scrofa 413 Veterinary science Placebo Injections Intramuscular 0403 veterinary science chemistry.chemical_compound Double-Blind Method Lactation sow medicine Animals farrowing Saline Finland Inflammation Pressure Ulcer Swine Diseases Creatinine General Veterinary biology business.industry Haptoglobin Anti-Inflammatory Agents Non-Steroidal Postpartum Period 0402 animal and dairy science 04 agricultural and veterinary sciences Feeding Behavior 040201 dairy & animal science 3. Good health stomatognathic diseases medicine.anatomical_structure chemistry Anesthesia biology.protein Mann–Whitney U test Body Constitution Animal Science and Zoology Creatine kinase Female business Constipation Blood Chemical Analysis medicine.drug |
| Zdroj: | Veterinary journal (London, England : 1997). 198(1) |
| ISSN: | 1532-2971 |
| Popis: | The effect of the non-steroidal anti-inflammatory drug ketoprofen on the post farrowing phase of sows was studied in a randomized, blinded, placebo-controlled trial. Ketoprofen (3mg/kg) was administered intramuscularly to 20 healthy sows for 3 days post-partum (p.p.). The control group (n=20) received a saline placebo. Backfat, number of days of constipation and days before feed refusal were measured. Body condition (BCS) and shoulder sores were scored for 1 week p.p. Changes in BCS, backfat and shoulder sore scores were analysed with ANOVA. Blood was collected on days -1, 0, 5 and 14 with respect to medication. Aspartate aminotransferase (AST), creatinine kinase (CK), haptoglobin and serum amyloid A (SAA) were quantified and analysed with a Mann-Whitney U test. BCS and backfat decreased less following ketoprofen administration than with the placebo (-0.08 ± 0.2 vs. -0.8 ± 0.2, 1.0 ± 0.8mm vs. -2.0 ± 0.9 mm, respectively; P0.05 for both) during the first 2 weeks of lactation. The shoulder sore score deterioration was milder during days 4-6 p.p. with ketoprofen than placebo (P0.05). Duration of constipation was shorter with ketoprofen than placebo (5.5 ± 0.3 vs. 6.4 ± 0.3 days p.p.; P0.05). Incidences of feed refusal occurred later in the ketoprofen group than in the placebos (9.6 ± 0.9 vs. 3.8 ± 0.8 days p.p.; P0.05). AST and SAA values were higher after ketoprofen administration than placebo on day 5 p.p. (P0.05). It was concluded that ketoprofen appeared to benefit sows during the first 2 weeks post farrowing, but caused some tissue irritation. |
| Databáze: | OpenAIRE |
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