Metformin Inhibits Growth of Hepatocellular Carcinoma Cells by Inducing Apoptosis Via Mitochondrion-mediated Pathway
| Autor: | Yu Xiong, Guo-Yang Wu, Qing-Jun Lu, Jing Zhao |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Carcinoma Hepatocellular endocrine system diseases Epidemiology Population Antineoplastic Agents Apoptosis Type 2 diabetes Pharmacology Resting Phase Cell Cycle AMP-Activated Protein Kinase Kinases Cell Line Tumor Pancreatic cancer Humans Medicine Phosphorylation education PI3K/AKT/mTOR pathway Cell Proliferation education.field_of_study business.industry TOR Serine-Threonine Kinases Liver Neoplasms G1 Phase Public Health Environmental and Occupational Health nutritional and metabolic diseases Cell Cycle Checkpoints Hep G2 Cells medicine.disease Metformin Mitochondria Oncology Hepatocellular carcinoma Signal transduction business Protein Kinases Signal Transduction medicine.drug |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 13:3275-3279 |
| ISSN: | 1513-7368 |
| Popis: | Recently, population-based studies of type 2 diabetes patients have provided evidence that metformin treatment is associated with a reduced cancer incidence and mortality, but its mode of action remains unclear. Here we report effects of metformin on hepatocellular carcinoma (HCC) Hep-G2 cells and details of molecular mechanisms of metformin activity. Our research indicates that metformin displays anticancer activity against HCC through inhibition of the mTOR translational pathway in an AMPK-independent manner, leading to G1 arrest in the cell-cycle and subsequent cell apoptosis through the mitochondrion-dependent pathway. Furthermore, we showed that metformin strongly attenuated colony formation and dramatically inhibited Hep-G2 tumor growth in vivo. In conclusion, our studies suggested that metformin might have potential as a cytotoxic drug in the prevention and treatment of HCC. |
| Databáze: | OpenAIRE |
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