The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19

Autor: Anna De Blasio, Daniela Carlisi, Marianna Lauricella, Michela Giuliano, Sonia Emanuele, Antonella D'Anneo, Adriana Celesia
Přispěvatelé: Emanuele S., Celesia A., D'anneo A., Lauricella M., Carlisi D., De Blasio A., Giuliano M.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Regulator
Anti-Inflammatory Agents
Disease
Review
environment and public health
NF-κB
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Settore BIO/10 - Biochimica
Neoplasms
oxidative stress
Biology (General)
Spectroscopy
General Medicine
respiratory system
Computer Science Applications
Chemistry
cell death
030220 oncology & carcinogenesis
Signal transduction
Signal Transduction
QH301-705.5
NF-E2-Related Factor 2
Context (language use)
Biology
Catalysis
Nrf2
Inorganic Chemistry
03 medical and health sciences
medicine
cancer
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Transcription factor
QD1-999
Organic Chemistry
Cancer
COVID-19
medicine.disease
COVID-19 Drug Treatment
030104 developmental biology
chemistry
inflammation
Cytokine storm
Neuroscience
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7963, p 7963 (2021)
ISSN: 1422-0067
Popis: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known transcription factor best recognised as one of the main regulators of the oxidative stress response. Beyond playing a crucial role in cell defence by transactivating cytoprotective genes encoding antioxidant and detoxifying enzymes, Nrf2 is also implicated in a wide network regulating anti-inflammatory response and metabolic reprogramming. Such a broad spectrum of actions renders the factor a key regulator of cell fate and a strategic player in the control of cell transformation and response to viral infections. The Nrf2 protective roles in normal cells account for its anti-tumour and anti-viral functions. However, Nrf2 overstimulation often occurs in tumour cells and a complex correlation of Nrf2 with cancer initiation and progression has been widely described. Therefore, if on one hand, Nrf2 has a dual role in cancer, on the other hand, the factor seems to display a univocal function in preventing inflammation and cytokine storm that occur under viral infections, specifically in coronavirus disease 19 (COVID-19). In such a variegate context, the present review aims to dissect the roles of Nrf2 in both cancer and COVID-19, two widespread diseases that represent a cause of major concern today. In particular, the review describes the molecular aspects of Nrf2 signalling in both pathological situations and the most recent findings about the advantages of Nrf2 inhibition or activation as possible strategies for cancer and COVID-19 treatment respectively.
Databáze: OpenAIRE
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